Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration

I Villalón-García, S Povea-Cabello… - Neural Regeneration …, 2023 - journals.lww.com
Lipid peroxidation and iron accumulation are closely associated with neurodegenerative
diseases, such as Alzheimer's, Parkinson's, and Huntington's diseases, or …

Proteostasis in aging-associated ocular disease

J Weinberg, M Gaur, A Swaroop, A Taylor - Molecular aspects of medicine, 2022 - Elsevier
Vision impairment has devastating consequences for the quality of human life. The cells and
tissues associated with the visual process must function throughout one's life span and …

Lipofuscin-like autofluorescence within microglia and its impact on studying microglial engulfment

JM Stillman, F Mendes Lopes, JP Lin, K Hu… - Nature …, 2023 - nature.com
Engulfment of cellular material and proteins is a key function for microglia, a resident
macrophage of the central nervous system (CNS). Among the techniques used to measure …

Role of death-associated protein kinase 1 (DAPK1) in retinal degenerative diseases: an in-silico approach towards therapeutic intervention

A Firoz, P Talwar - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
The Death-associated protein kinase 1 (DAPK1) has emerged as a crucial player in the
pathogenesis of degenerative diseases. As a serine/threonine kinase family member …

Importance of optical coherence tomography and optical coherence tomography angiography in the imaging and differentiation of choroidal melanoma: a review

I Obuchowska, J Konopińska - Cancers, 2022 - mdpi.com
Simple Summary Choroidal melanoma is a highly malignant intraocular neoplasm. It is the
most prevalent intraocular tumor in adults and it derives from melanocytes; the liver is the …

Antioxidants Prevent iron accumulation and lipid peroxidation, but do not correct autophagy dysfunction or mitochondrial bioenergetics in cellular models of BPAN

A Suárez-Carrillo, M Álvarez-Córdoba… - International Journal of …, 2023 - mdpi.com
Neurodegeneration with brain iron accumulation (NBIA) is a group of rare neurogenetic
disorders frequently associated with iron accumulation in the basal nuclei of the brain …

神经退行性变中脂质过氧化和铁积累的恶性循环

I Villalón-García, S Povea-Cabello… - 中国神经再生研究 …, 2023 - sjzsyj.com.cn
Lipid peroxidation and iron accumulation are closely associated with neurodegenerative
diseases, such as Alzheimer's, Parkinson's, and Huntington's diseases, or …

Effect of modifiable lifestyle risk factors on the incidence and prevention of cancer in modern society: A review.

N Bhattacharjee, T Sarkar - Annals of the National Academy …, 2024 - search.ebscohost.com
Human society has been influenced by modernization, which has altered our pattern of
living. It is believed that several environmental and lifestyle factors, including urbanization …

A glance on antioxidants: The role of sulfur amino acids in retinal disorders

V Castelli, L Byrd-Leotis, R Novelli, L Brandolini… - Modulation of Oxidative …, 2023 - Elsevier
Retinal diseases are primary reasons of blindness and are due to an imbalance between
reactive oxygen species and antioxidant scavenger or a disruption of redox signaling and …

Molecular mechanisms of TIMP-3 turnover in Sorsby Fundus Dystrophy

JHJ Betts - 2024 - ueaeprints.uea.ac.uk
Sorsby fundus dystrophy (SFD) is an autosomal dominant macular dystrophy, caused by
mutations in tissue inhibitor of metalloproteinases 3 (TIMP-3), leading to central vision loss …