Liposome and immune system interplay: Challenges and potentials

F Zahednezhad, M Saadat, H Valizadeh… - Journal of Controlled …, 2019 - Elsevier
Liposome as a revolutionizing carrier, has exhibited favorable aspects in drug delivery.
However, there are numerous challenges affecting its effectiveness. Hypersensitivity …

Zwitterionic‐coated “stealth” nanoparticles for biomedical applications: recent advances in countering biomolecular corona formation and uptake by the mononuclear …

KP García, K Zarschler, L Barbaro, JA Barreto… - Small, 2014 - Wiley Online Library
Nanoparticles represent highly promising platforms for the development of imaging and
therapeutic agents, including those that can either be detected via more than one imaging …

Nanocarriers' entry into the cell: relevance to drug delivery

H Hillaireau, P Couvreur - Cellular and molecular life sciences, 2009 - Springer
Nanocarriers offer unique possibilities to overcome cellular barriers in order to improve the
delivery of various drugs and drug candidates, including the promising therapeutic …

Passive and active drug targeting: drug delivery to tumors as an example

VP Torchilin - Drug delivery, 2010 - Springer
The paradigm of using nanoparticulate pharmaceutical carriers has been well established
over the past decade, both in pharmaceutical research and in the clinical setting. Drug …

Challenges in development of targeted liposomal therapeutics

RR Sawant, VP Torchilin - The AAPS journal, 2012 - Springer
Liposomes, phospholipid vesicles with a bilayered membrane structure, have been widely
used as pharmaceutical carriers for drugs and genes, in particular for treatment of cancer. To …

Therapeutic inflammatory monocyte modulation using immune-modifying microparticles

DR Getts, RL Terry, MT Getts, C Deffrasnes… - Science translational …, 2014 - science.org
Inflammatory monocyte-derived effector cells play an important role in the pathogenesis of
numerous inflammatory diseases. However, no treatment option exists that is capable of …

Targeted liposomal drug delivery to monocytes and macrophages

C Kelly, C Jefferies, SA Cryan - Journal of drug delivery, 2011 - Wiley Online Library
As the role of monocytes and macrophages in a range of diseases is better understood,
strategies to target these cell types are of growing importance both scientifically and …

Parameters influencing the stealthiness of colloidal drug delivery systems

A Vonarbourg, C Passirani, P Saulnier, JP Benoit - Biomaterials, 2006 - Elsevier
Over the last few decades, colloidal drug delivery systems (CDDS) such as nano-structures
have been developed in order to improve the efficiency and the specificity of drug action …

Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes

T Ishida, M Ichihara, XY Wang, K Yamamoto… - Journal of Controlled …, 2006 - Elsevier
Steric stabilization of the surface of liposomes by a PEG conjugated lipid results in reduced
recognition of the liposomes by the cells of the mononuclear phagocyte system and …

Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens

DS Watson, AN Endsley, L Huang - Vaccine, 2012 - Elsevier
Liposomes (phospholipid bilayer vesicles) are versatile and robust delivery systems for
induction of antibody and T lymphocyte responses to associated subunit antigens. In the last …