[HTML][HTML] Farnesoid X receptor as target for therapies to treat cholestasis-induced liver injury

AD Petrescu, S DeMorrow - Cells, 2021 - mdpi.com
Recent studies on liver disease burden worldwide estimated that cirrhosis is the 11th most
common cause of death globally, and there is a great need for new therapies to limit the …

[HTML][HTML] Unraveling the complex interplay between epigenetics and immunity in alcohol-associated liver disease: A comprehensive review

Y Liu, T Liu, F Zhang, Y Gao - International Journal of Biological …, 2023 - ncbi.nlm.nih.gov
The mechanisms of immune dysfunction in alcohol-associated liver disease (ALD) have
garnered growing research interest in recent times. Alcohol-mediated immune dysfunction …

Antarctic krill oil ameliorates liver injury in rats exposed to alcohol by regulating bile acids metabolism and gut microbiota

P Guo, M Xue, X Teng, Y Wang, R Ren, J Han… - The Journal of …, 2022 - Elsevier
Bile acids (BAs) metabolism plays an important role in alcohol liver disease through the gut
microflora-bile acids-liver axis. Antarctic Krill Oil (AKO) has protective effects on the liver …

[HTML][HTML] New insights into the bile acid-based regulatory mechanisms and therapeutic perspectives in alcohol-related liver disease

Y Liu, T Liu, X Zhao, Y Gao - Cellular and Molecular Life Sciences, 2022 - Springer
Cholestasis is a key causative factor in alcohol-related liver disease (ALD) and variable
degrees of cholestasis occur in all stages of ALD. However, the pathogenetic mechanisms …

[HTML][HTML] Emerging medical therapies for severe alcoholic hepatitis

D Tornai, G Szabo - Clinical and Molecular Hepatology, 2020 - ncbi.nlm.nih.gov
Severe alcoholic hepatitis (AH) is an acute and often devastating form of alcohol-associated
liver disease. Clinically, AH is characterized by elevated bilirubin, model for end stage liver …

Severe alcoholic hepatitis: current perspectives

CA Philips, P Augustine, PK Yerol… - Hepatic medicine …, 2019 - Taylor & Francis
Severe acute alcoholic hepatitis (AH) is a catastrophic disease in the natural history of
alcoholic liver disease with a very high 180-day mortality. It can present as acute on chronic …

Current and future treatment for alcoholic‐related liver diseases

EL Yoon, W Kim - Journal of Gastroenterology and Hepatology, 2023 - Wiley Online Library
The socioeconomic burden of alcohol‐related liver disease has been increasing worldwide.
Its prevalence is underestimated, and patients with alcohol‐related liver disease are rarely …

Acute alcoholic hepatitis

GY Im - Clinics in liver disease, 2019 - liver.theclinics.com
Alcoholic hepatitis (AH) is a unique type of alcohol-associated liver disease (ALD)
characterized by acute liver inflammation caused by prolonged heavy alcohol use. The short …

[HTML][HTML] Current and emerging therapies for alcohol-associated hepatitis

F Idalsoaga, G Ayares, LA Díaz, J Arnold… - Liver Research, 2023 - Elsevier
Alcohol-related liver disease (ALD) encompasses a spectrum of diseases caused by
excessive alcohol consumption. ALD includes hepatic steatosis, steatohepatitis, variable …

Alcoholic and non-alcoholic liver diseases: Promising molecular drug targets and their clinical development

K Thapa, AS Grewal, N Kanojia, L Rani… - Current Drug …, 2021 - ingentaconnect.com
Alcoholic and non-alcoholic fatty liver diseases have become a serious concern worldwide.
Both these liver diseases have an identical pathology, starting from simple steatosis to …