Exosomes as messengers between mother and fetus in pregnancy

L Czernek, M Düchler - International Journal of Molecular Sciences, 2020 - mdpi.com
The ability of exosomes to transport different molecular cargoes and their ability to influence
various physiological factors is already well known. An exciting area of research explores …

Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ systems, differing mechanisms, and pathways

MS Vidal Jr, RCV Lintao, MEL Severino… - Frontiers in …, 2022 - frontiersin.org
Survivors of preterm birth struggle with multitudes of disabilities due to improper in utero
programming of various tissues and organ systems contributing to adult-onset diseases at a …

Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis

L Zhao, C Gu, Y Gan, L Shao, H Chen, H Zhu - Journal of Controlled …, 2020 - Elsevier
High recurrence and metastasis of triple-negative breast cancer (TNBC) after operation is a
leading cause of breast cancer related death. The pre-metastatic niche (PMN) is an …

[HTML][HTML] Extracellular vesicles derived from M1 macrophages deliver miR-146a-5p and miR-146b-5p to suppress trophoblast migration and invasion by targeting …

J Ding, Y Zhang, X Cai, Y Zhang, S Yan, J Wang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Emerging evidence demonstrates that insufficient migration and invasion of
trophoblasts play critical roles in the pathogenesis of recurrent spontaneous abortion (RSA) …

Methotrexate-loaded extracellular vesicles functionalized with therapeutic and targeted peptides for the treatment of glioblastoma multiforme

Z Ye, T Zhang, W He, H Jin, C Liu… - ACS applied materials …, 2018 - ACS Publications
Despite promising in vitro evidence for effective glioblastoma treatment, most drugs are
hindered from entering the central nervous system because of the presence of the blood …

Exosomes secreted by endothelial progenitor cells accelerate bone regeneration during distraction osteogenesis by stimulating angiogenesis

Y Jia, Y Zhu, S Qiu, J Xu, Y Chai - Stem cell research & therapy, 2019 - Springer
Background Distraction osteogenesis (DO) is an effective but lengthy procedure to fully
induce bone regeneration in large bone defects. Accumulating evidence supports the role of …

Exosomes from women with preeclampsia induced vascular dysfunction by delivering sFlt (soluble Fms-like tyrosine kinase)-1 and sEng (soluble endoglin) to …

X Chang, J Yao, Q He, M Liu, T Duan, K Wang - Hypertension, 2018 - Am Heart Assoc
Preeclampsia is a unique multiple system disorder that affects 5% to 8% of pregnancies.
Exosomes, membrane-encapsulated vesicles that are released into the extracellular …

Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small …

P Lara, S Palma-Florez, E Salas-Huenuleo… - Journal of …, 2020 - Springer
Abstract Background Extracellular vesicles (EVs) have shown great potential for targeted
therapy, as they have a natural ability to pass through biological barriers and, depending on …

Amniotic fluid exosome proteomic profile exhibits unique pathways of term and preterm labor

CL Dixon, S Sheller-Miller, GR Saade… - …, 2018 - academic.oup.com
Our objective was to determine the amniotic fluid–derived exosomal proteomic profile in
patients who had spontaneous preterm birth (PTB) or preterm premature rupture of …

Extracellular vesicles as innovative tool for diagnosis, regeneration and protection against neurological damage

P Andjus, M Kosanović, K Milićević, M Gautam… - International journal of …, 2020 - mdpi.com
Extracellular vesicles (EVs) have recently attracted a great deal of interest as they may
represent a new biosignaling paradigm. According to the mode of biogenesis, size and …