Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …

The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays
essential roles in tumor development and metastasis. The clinical outcomes of tumors are …

The molecular circuits by which antigens activate quiescent T cells remain poorly
understood. We combined temporal profiling of the whole proteome and phosphoproteome …

Naive T cells respond to antigen stimulation by exiting from quiescence and initiating clonal
expansion and functional differentiation, but the control mechanism is elusive. Here we …

Extracellular ATP is a danger signal released by dying and damaged cells, and it functions
as an immunostimulatory signal that promotes inflammation. However, extracellular …

Previous studies revealed the existence of foreign antigen-specific memory phenotype CD8
T cells in unimmunized mice. Considerable evidence suggests this population, termed …

Systemic lupus erythematosus (SLE) is a devastating autoimmune disease in which
hyperactive T cells play a critical role. Understanding molecular mechanisms underlying the …

Tumor-reactive T cells become unresponsive in advanced tumors. Here we have
characterized a common mechanism of T cell unresponsiveness in cancer driven by the …

Immunity following an acutely resolved infection or the long-term equipoise of chronic viral
infections often depends on the maintenance of antigen-specific CD8+ T cells, yet the …