[HTML][HTML] Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease
Inflammation occurs as a result of exposure of tissues and organs to harmful stimuli such as
microbial pathogens, irritants, or toxic cellular components. The primary physical …
microbial pathogens, irritants, or toxic cellular components. The primary physical …
Molecular mechanisms of action of anti-TNF-α agents–Comparison among therapeutic TNF-α antagonists
H Mitoma, T Horiuchi, H Tsukamoto, N Ueda - Cytokine, 2018 - Elsevier
Tumor necrosis factor (TNF)-α is a potent pro-inflammatory and pathological cytokines in
inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases. Anti …
inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases. Anti …
Transmembrane TNF-α: structure, function and interaction with anti-TNF agents
T Horiuchi, H Mitoma, S Harashima… - …, 2010 - academic.oup.com
Transmembrane TNF-α, a precursor of the soluble form of TNF-α, is expressed on activated
macrophages and lymphocytes as well as other cell types. After processing by TNF-α …
macrophages and lymphocytes as well as other cell types. After processing by TNF-α …
Tumor necrosis factor antagonist mechanisms of action: a comprehensive review
D Tracey, L Klareskog, EH Sasso, JG Salfeld… - Pharmacology & …, 2008 - Elsevier
During the past 30 years, elucidation of the pathogenesis of rheumatoid arthritis, Crohn's
disease, psoriasis, psoriatic arthritis and ankylosing spondylitis at the cellular and molecular …
disease, psoriasis, psoriatic arthritis and ankylosing spondylitis at the cellular and molecular …
TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
MK McCoy, MG Tansey - Journal of neuroinflammation, 2008 - Springer
The role of tumor necrosis factor (TNF) as an immune mediator has long been appreciated
but its function in the brain is still unclear. TNF receptor 1 (TNFR1) is expressed in most cell …
but its function in the brain is still unclear. TNF receptor 1 (TNFR1) is expressed in most cell …
Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system
SL Montgomery, WJ Bowers - Journal of neuroimmune pharmacology, 2012 - Springer
Abstract Tumor Necrosis Factor-alpha (TNF-α) is a prototypic pro-inflammatory cytokine
involved in the innate immune response. TNF-α ligation and downstream signaling with one …
involved in the innate immune response. TNF-α ligation and downstream signaling with one …
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci
A genome-wide association study was performed to identify genetic factors involved in
susceptibility to psoriasis (PS) and psoriatic arthritis (PSA), inflammatory diseases of the skin …
susceptibility to psoriasis (PS) and psoriatic arthritis (PSA), inflammatory diseases of the skin …
Interleukin-12: biological properties and clinical application
M Del Vecchio, E Bajetta, S Canova, MT Lotze… - Clinical Cancer …, 2007 - AACR
Abstract Interleukin-12 (IL-12) is a heterodimeric protein, first recovered from EBV-
transformed B cell lines. It is a multifunctional cytokine, the properties of which bridge innate …
transformed B cell lines. It is a multifunctional cytokine, the properties of which bridge innate …
iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS
DR McIlwain, PA Lang, T Maretzky, K Hamada… - Science, 2012 - science.org
Innate immune responses are vital for pathogen defense but can result in septic shock when
excessive. A key mediator of septic shock is tumor necrosis factor–α (TNFα), which is shed …
excessive. A key mediator of septic shock is tumor necrosis factor–α (TNFα), which is shed …