The biologically relevant coordination chemistry of iron and nitric oxide: electronic structure and reactivity

N Lehnert, E Kim, HT Dong, JB Harland… - Chemical …, 2021 - ACS Publications
Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Redox and spectroscopic properties of mammalian nitrite reductase-like hemoproteins

Y Zheng, W Deng, D Liu, Y Li, K Peng… - Journal of Inorganic …, 2022 - Elsevier
Besides the canonical pathway of L-arginine oxidation to produce nitric oxide (NO) in vivo,
the nitrate-nitrite-NO pathway has been widely accepted as another source for circulating …

Repurposing a Nitric Oxide Transport Hemoprotein Nitrophorin 2 for Olefin Cyclopropanation

S Huang, WH Deng, RZ Liao, C He - ACS Catalysis, 2022 - ACS Publications
A growing number of heme proteins have recently been repurposed for catalyzing
abiological carbene transfer reactions. Herein, we rationally designed an engineered variant …

Chemical Synthesis of the 20 kDa Heme Protein Nitrophorin 4 by α‐Ketoacid‐Hydroxylamine (KAHA) Ligation

C He, SS Kulkarni, F Thuaud… - Angewandte Chemie …, 2015 - Wiley Online Library
The chemical synthesis of the 184‐residue ferric heme‐binding protein nitrophorin 4 was
accomplished by sequential couplings of five unprotected peptide segments using α …

Nitrosyl Myoglobins and Their Nitrite Precursors: Crystal Structural and Quantum Mechanics and Molecular Mechanics Theoretical Investigations of Preferred FeNO …

B Wang, Y Shi, J Tejero, SM Powell, LM Thomas… - Biochemistry, 2018 - ACS Publications
The globular dioxygen binding heme protein myoglobin (Mb) is present in several species.
Its interactions with the simple nitrogen oxides, namely, nitric oxide (NO) and nitrite, have …

Nitrite dismutase reaction mechanism: Kinetic and spectroscopic investigation of the interaction between nitrophorin and nitrite

C He, BD Howes, G Smulevich, S Rumpel… - Journal of the …, 2015 - ACS Publications
Nitrite is an important metabolite in the physiological pathways of NO and other nitrogen
oxides in both enzymatic and nonenzymatic reactions. The ferric heme b protein nitrophorin …

Distinguishing Nitro vs Nitrito Coordination in Cytochrome c′ Using Vibrational Spectroscopy and Density Functional Theory

ZN Nilsson, BL Mandella, K Sen, D Kekilli… - Inorganic …, 2017 - ACS Publications
Nitrite coordination to heme cofactors is a key step in the anaerobic production of the
signaling molecule nitric oxide (NO). An ambidentate ligand, nitrite has the potential to …

Elucidation of the heme active site electronic structure affecting the unprecedented nitrite dismutase activity of the ferriheme b proteins, the nitrophorins

C He, H Ogata, W Lubitz - Chemical Science, 2016 - pubs.rsc.org
Nitrophorins (NPs) catalyze the nitrite dismutation reaction that is unprecedented in
ferriheme proteins. Despite progress in studying the reaction mechanism, fundamental …

Complexes of ferriheme nitrophorin 4 with low-molecular weight thiol (ate) s occurring in blood plasma

C He, K Nishikawa, ÖF Erdem, E Reijerse… - Journal of Inorganic …, 2013 - Elsevier
Nitrophorins are proteins occurring in the saliva of the blood-sucking insect Rhodnius
prolixus to carry NO as a vasodilator and blood-coagulation inhibitor into the victim's tissue …

Measuring of time-series concentrations of nutrients in surface waters using osmotic sampler with air bubble segmentation and preservative addition

J Pei, D Yuan, Q Li, K Lin, B Lu, N Chen, J Du - Science of The Total …, 2021 - Elsevier
The analysis of time-series concentrations (C TS) is of great importance when investigating
the biogeochemical processes of nutrients in aquatic environments. However, obtaining C …