The liver, a component of the gastrointestinal tract, is one of the most important organs in the
human body. The liver performs over 500 functions to promote physiological homeostasis. In …

The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore
up to 70% of its volume. Although knowledge of this phenomenon dates back to Greek …

Despite the well‐known hepatoprotective role of the epidermal growth factor receptor
(EGFR) pathway upon acute damage, its specific actions during chronic liver disease …

Bone morphogenetic proteins (BMPs) are a group of growth factors belonging to the
transforming growth factor β (TGF-β) family. While initially recognized for their role in bone …

Background BMP9, originating from the liver, and BMP10 are circulating BMPs that preserve
vascular endothelial integrity. We assessed BMP9, BMP10 and soluble endoglin (sEng) …

Fibrosis is a common feature in most pathogenetic processes in the liver, and usually results
from a chronic insult that depletes the regenerative capacity of hepatocytes and activates …

Liver fibrosis resulting from chronic liver injury is a key factor to develop liver cirrhosis and
risk of hepatocellular carcinoma (HCC) which are major health burden worldwide …

Background The liver is renowned for its remarkable regenerative capacity to restore its
structure, size and function after various types of liver injury. However, in patients with end …

The malignant nature of hepatocellular carcinoma (HCC) is closely related to the presence
of cancer stem cells (CSCs). Bone morphologic protein 9 (BMP9), a member of the …

The aim of the present work was to address the role of BMP9 in different genetic
backgrounds (C57BL/6, BALB/c, and 129/Ola) of mice deleted for Bmp9. We found that …