Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations

JL Rodriguez-Flores, K Fakhro, F Agosto-Perez… - Genome …, 2016 - genome.cshlp.org
An open question in the history of human migration is the identity of the earliest Eurasian
populations that have left contemporary descendants. The Arabian Peninsula was the initial …

A 1000 Arab genome project to study the Emirati population

M Al-Ali, W Osman, GK Tay, HS AlSafar - Journal of human genetics, 2018 - nature.com
Discoveries from the human genome, HapMap, and 1000 genome projects have collectively
contributed toward the creation of a catalog of human genetic variations that has improved …

Heterogeneity in biomarkers, mitogenome and genetic disorders of the Arab population with special emphasis on large-scale whole-exome sequencing

JF Borgio - Archives of Medical Science: AMS, 2021 - pmc.ncbi.nlm.nih.gov
More than 25 million DNA variations have been discovered as novel including major alleles
from the Arab population. Exome studies on the Saudi genome discovered> 3000 novel …

Genome-wide characterization of Arabian Peninsula populations: shedding light on the history of a fundamental bridge between continents

V Fernandes, N Brucato, JC Ferreira… - Molecular biology …, 2019 - academic.oup.com
Abstract The Arabian Peninsula (AP) was an important crossroad between Africa, Asia, and
Europe, being the cradle of the structure defining these main human population groups, and …

Genetic diversity and low stratification of the population of the United Arab Emirates

GK Tay, A Henschel, G Daw Elbait, HS Al Safar - Frontiers in Genetics, 2020 - frontiersin.org
With high consanguinity rates on the Arabian Peninsula, it would not have been unexpected
if the population of the United Arab Emirates (UAE) was shown to be relatively homogenous …

A population-specific major allele reference genome from the United Arab Emirates population

G Daw Elbait, A Henschel, GK Tay, HS Al Safar - Frontiers in Genetics, 2021 - frontiersin.org
The ethnic composition of the population of a country contributes to the uniqueness of each
national DNA sequencing project and, ideally, individual reference genomes are required to …

Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics

SE John, D Antony, M Eaaswarkhanth, P Hebbar… - Scientific reports, 2018 - nature.com
Consanguineous populations of the Arabian Peninsula have been underrepresented in
global efforts that catalogue human exome variability. We sequenced 291 whole exomes of …

Introducing the first whole genomes of nationals from the United Arab Emirates

HS AlSafar, M Al-Ali, GD Elbait, MH Al-Maini, D Ruta… - Scientific Reports, 2019 - nature.com
Abstract Whole Genome Sequencing (WGS) provides an in depth description of genome
variation. In the era of large-scale population genome projects, the assembly of ethnic …

Mitochondrial haplogroup R offers protection against obesity in Kuwaiti and Qatari populations

M Dashti, NM Ali, H Alsaleh, SE John… - Frontiers in …, 2024 - frontiersin.org
Background The Kuwaiti and Qatari populations have a high prevalence of obesity, a major
risk factor for various metabolic disorders. Previous studies have independently explored …

Evaluation of HLA typing content of next-generation sequencing datasets from family trios and individuals of arab ethnicity

M Dashti, MZ Malik, R Nizam, S Jacob, F Al-Mulla… - Frontiers in …, 2024 - frontiersin.org
Introduction: HLA typing is a critical tool in both clinical and research applications at the
individual and population levels. Benchmarking studies have indicated HLA-HD as the …