In vivo real-time imaging reveals megalin as the aminoglycoside gentamicin transporter into cochlea whose inhibition is otoprotective
Aminoglycosides (AGs) are commonly used antibiotics that cause deafness through the
irreversible loss of cochlear sensory hair cells (HCs). How AGs enter the cochlea and then …
irreversible loss of cochlear sensory hair cells (HCs). How AGs enter the cochlea and then …
A chemo-mechanical cochleostomy preserves hearing for the in vivo functional imaging of cochlear cells
In vivo and real-time multicellular imaging enables the decoding of sensory circuits and the
tracking of systemic drug uptake. However, in vivo imaging of the auditory periphery remains …
tracking of systemic drug uptake. However, in vivo imaging of the auditory periphery remains …
Cochlear motion across the reticular lamina implies that it is not a stiff plate
Within the cochlea, the basilar membrane (BM) is coupled to the reticular lamina (RL)
through three rows of piezo-like outer hair cells (OHCs) and supporting cells that endow …
through three rows of piezo-like outer hair cells (OHCs) and supporting cells that endow …
Dye tracking following posterior semicircular canal or round window membrane injections suggests a role for the cochlea aqueduct in modulating distribution
S Talaei, ME Schnee, KA Aaron… - Frontiers in Cellular …, 2019 - frontiersin.org
The inner ear houses the sensory epithelium responsible for vestibular and auditory
function. The sensory epithelia are driven by pressure and vibration of the fluid filled …
function. The sensory epithelia are driven by pressure and vibration of the fluid filled …
Motion of the cochlear reticular lamina varies radially across outer-hair-cell rows
The basilar membrane (BM) is connected to the reticular lamina (RL) through three rows of Y-
shaped structures consisting of an outer hair cell (OHC) and a Deiters' cell (DC) with a …
shaped structures consisting of an outer hair cell (OHC) and a Deiters' cell (DC) with a …
The future of otology
RK Jackler, TA Jan - The Journal of Laryngology & Otology, 2019 - cambridge.org
BackgroundThe field of otology is increasingly at the forefront of innovation in science and
medicine. The inner ear, one of the most challenging systems to study, has been rendered …
medicine. The inner ear, one of the most challenging systems to study, has been rendered …
Restoring hearing with neural prostheses: current status and future directions
This chapter provides a brief history and description of the cochlear implant, which is
considered one of the most successful neural prostheses to date. Although the cochlear …
considered one of the most successful neural prostheses to date. Although the cochlear …