Sedentary behavior and the biological hallmarks of aging

J Raffin, P de Souto Barreto, AP Le Traon… - Ageing Research …, 2023 - Elsevier
While the benefits of physical exercise for a healthy aging are well-recognized, a growing
body of evidence shows that sedentary behavior has deleterious health effects …

Biological mechanisms to reduce radioresistance and increase the efficacy of radiotherapy: state of the art

F Busato, BE Khouzai, M Mognato - International journal of molecular …, 2022 - mdpi.com
Cancer treatment with ionizing radiation (IR) is a well-established and effective clinical
method to fight different types of tumors and is a palliative treatment to cure metastatic …

Radiation-induced ophthalmic risks of long duration spaceflight: Current investigations and interventions

E Waisberg, J Ong, P Paladugu… - European Journal …, 2024 - journals.sagepub.com
Purpose As the average duration of space missions increases, astronauts will experience
longer periods of exposure to risks of long duration space flight including microgravity and …

Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology

H Cope, J Elsborg, S Demharter, JT McDonald… - Communications …, 2024 - nature.com
Background Spaceflight poses a unique set of challenges to humans and the hostile
spaceflight environment can induce a wide range of increased health risks, including …

Cancer studies under space conditions: Finding answers abroad

JL Cortés-Sánchez, J Callant, M Krüger, J Sahana… - Biomedicines, 2021 - mdpi.com
In this review article, we discuss the current state of knowledge in cancer research under
real and simulated microgravity conditions and point out further research directions in this …

[HTML][HTML] Leukemic stem cells and advances in hematopoietic stem cell transplantation for acute myeloid leukemia: A narrative review of clinical trials

V Sumbly, I Landry, C Sneed, Q Iqbal… - Stem Cell …, 2022 - ncbi.nlm.nih.gov
Objective The purpose of this literature review is to summarize and provide a brief overview
of our current understanding of acute myeloid leukemia (AML) and the role of stem cell …

[HTML][HTML] More than a feeling: Dermatological changes impacted by spaceflight

H Cope, J Elsborg, S Demharter, JT Mcdonald… - Research …, 2023 - ncbi.nlm.nih.gov
Spaceflight poses a unique set of challenges to humans and the hostile Spaceflight
environment can induce a wide range of increased health risks, including dermatological …

[HTML][HTML] Mission SpaceX CRS-19 RRRM-1 space flight induced skin genomic plasticity via an epigenetic trigger

K Singh, P Verma, R Srivastava, Y Rustagi, M Kumar… - iScience, 2024 - cell.com
Genomic plasticity helps adapt to extreme environmental conditions. We tested the
hypothesis that exposure to space environment (ESE) impacts the epigenome inducing …

Food Fermentation in Space Is Possible, Distinctive, and Beneficial

M Coblentz, JD Evans, CI Kothe, T Mak… - bioRxiv, 2024 - biorxiv.org
Space exploration is expanding, which demands new technologies and enables new
scientific questions. Food, as a bridge between disciplines, can bring these fundamental and …

Fractionated Proton Irradiation Does Not Impair Hippocampal-Dependent Short-Term or Spatial Memory in Female Mice

P Simmons, C Corley, AR Allen - Toxics, 2022 - mdpi.com
The environment outside the Earth's protective magnetosphere is a much more threatening
and complex space environment. The dominant causes for radiation exposure, solar particle …