Apoptosis, an important form of programmed cell death (PCD), is a tightly regulated cellular
process to eliminate unwanted or damaged cells. Resistance of apoptosis is a hallmark of …

In the field of drug discovery, some classes of proteins have been deemed undruggable.
This typically means that no small molecule (≤ 800 Da) has been found that is capable of …

Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3
ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial …

Abstract The Inhibitor of Apoptosis proteins (IAPs) are a family of proteins that are mainly
known for their anti-apoptotic activity and ability to directly bind and inhibit caspases. Recent …

There is growing interest within the pharmaceutical community to undertake biological
targets that involve protein− protein 1 and, in general, biomacromolecular interactions 2 (PPI …

Highlights•XIAP harbors prosurvival, proapoptotic and nonapoptotic functions.•Proapoptotic
BH3-only protein Bim can regulate XIAP translocation to mitochondria.•XIAP induces Bax …

Necroptosis is generally considered as an inflammatory cell death form. The core regulators
of necroptotic signaling are receptor‐interacting serine–threonine protein kinases 1 (RIPK1) …

An expanded CUG repeat transcript (CUGexp) is the causative agent of myotonic dystrophy
type 1 (DM1) by sequestering muscleblind-like 1 protein (MBNL1), a regulator of alternative …

The first synthesis of eight-membered N-containing heterocycles by oxidative
bicyclization/ring extension of arylacetylenes and aryl amines has been achieved. This …

This first book on nanocellulose and nanohydrogels for biomedical applications is unique in
discussing recent advancements in the field, resulting in a comprehensive, well-structured …