The physiological role of estrogen in the female endometrium is well established. On the
basis of responses to steroid hormones (progesterone, androgen, and estrogen), the …

Endometrial cancer is the most common gynecological cancer in the developed world, and it
is one of the few cancer types that is becoming more prevalent and leading to more deaths …

Background Risk-assessment of endometrial cancer (EC) is based on clinicopathological
factors and molecular subgroup. It is unclear whether adding hormone receptor expression …

Estrogen is a steroid hormone that has critical roles in reproductive development, bone
homeostasis, cardiovascular remodeling and brain functions. However, estrogen also …

Introduction: Endometrial cancer is the most common gynaecological cancer and its
incidence is rising due to increasing obesity rates. We are also seeing an increasing trend of …

Background Anti-oestrogenic therapy has been used for breast cancer patients with
oestrogen susceptibility cancer cells. However, little has been known about its potential role …

Estrogen receptor (ER) is a member of the nuclear receptor superfamily whose members
share conserved domain structures, including a DNA-binding domain (DBD) and ligand …

The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in
RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly …

The study aimed to explore the relationship between miR-9-5p and ESR1, and clarify the
underlying functional mechanism in the occurrence and development of hepatocellular …

Estrogen signaling through estrogen receptor alpha (ER) plays a major role in endometrial
cancer risk and progression, however, the molecular mechanisms underlying ER's …