Due to the obvious advantages of long-acting peptide and protein drugs, strategies to
prolong plasma half life time of such compounds are highly on demand. Short plasma half …

The biodegradable polymers poly (lactic/glycolic acid)(PLGA) and poly (lactic acid)(PLA)
were used as wall materials in the preparation of microspheres (msp) containing the LH-RH …

Context In men who develop an elevated serum prostate-specific antigen level (PSA) after
having undergone a radical prostatectomy, the natural history of progression to distant …

To obtain a three-month release injection of leuprorelin acetate, microspheres were
prepared with copoly (DL-lactic/glycolic acid) or poly (DL-lactic acid)(PLA) using an in-water …

The development of the luteinizing hormone-releasing hormone (LH-RH) agonists and
antagonists and the principles of their clinical use were reviewed. In the 28 years that have …

OBJECTIVES: To compare the efficacy and safety of goserelin and orchiectomy in patients
with Stage D2 prostate cancer. METHODS: A randomized, open, multicenter study was …

Purpose: We compared the endocrinological and biochemical efficacy of abarelix depot, a
gonadotropin-releasing hormone antagonist, with that of a widely used combination of …

Leuprorelin acetate is a synthetic agonist analogue of gonadotropin-releasing hormone.
Continued leuprorelin administration results in suppression of gonadal steroid synthesis …

The excellent properties of polyesters combined with their ease of synthesis and
modification enabled their wide use in the pharmaceutical industry. This has been translated …

PURPOSE: Agonistic analogs of luteinizing hormone-releasing hormone (LHRH) are widely
used for therapy of advanced prostate cancer based upon their ability to suppress …