De novo drug design aims to generate molecules from scratch that possess specific
chemical and pharmacological properties. We present a computational approach utilizing …

Abstract Nitro-fatty acids (NO 2-FAs) are endogenous pleiotropic lipid mediators regarded as
promising drug candidates for treating inflammatory and fibrotic diseases. Over the past two …

Glioblastoma multiforme (GBM) is a highly invasive brain malignancy originating from
astrocytes, accounting for approximately 30% of central nervous system malignancies …

Peroxisome proliferator-activated receptors (PPARs), including PPAR-α, PPAR-β/δ, and
PPAR-γ, are involved in various cellular responses, including metabolism and cell …

Breakthrough symptoms are thought to occur in roughly half of all gastroesophageal reflux
disease (GERD) patients despite maximal acid suppression (proton pump inhibitor, PPI) …

Obesity, influenced by environmental pollutants, can lead to complex metabolic disruptions.
This systematic review and meta-analysis examined the molecular mechanisms underlying …

A novel series of thiazolidinedione derivatives (D1-D30) were designed, synthesized, and
characterized for potential anti-diabetic activity. Compounds D6, D8, and D24 emerged as …

Ovarian cancer (OC) ranks as the fifth leading factor for female mortality globally, with a
substantial burden of new cases and mortality recorded annually. Survival rates vary …

Tumor metabolism is crucial in the continuous advancement and complex growth of cancer.
The emerging field of nanotechnology has made significant strides in enhancing the …

Background: Myocardial infarction causes mitochondrial atrophy and loss of function by
reducing mitochondrial volume. Therefore, researchers are interested in finding a way to …