The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Background Despite initial reports of a decline in use in the early 2000s, methamphetamine
remains a significant public health concern with known neurotoxic and neurocognitive …

The allostatic load model expands the stress-disease literature by proposing a temporal
cascade of multi-systemic physiological dysregulations that contribute to disease …

Stress is a well‐known risk factor in the development of addiction and in addiction relapse
vulnerability. A series of population‐based and epidemiological studies have identified …

Drug addiction is increasingly viewed as the endpoint of a series of transitions from initial
drug use—when a drug is voluntarily taken because it has reinforcing, often hedonic, effects …

Mice experiencing repeated aggression develop a long-lasting aversion to social contact,
which can be normalized by chronic, but not acute, administration of antidepressant. Using …

Addiction science would benefit from the identification of a behavioral marker. A behavioral
marker could reflect the projected clinical course of the disorder, function as a surrogate …

This review discusses the evidence for the hypothesis that the development of drug
addiction can be understood in terms of interactions between Pavlovian and instrumental …

We have recently shown that damage to the insula leads to a profound disruption of
addiction to cigarette smoking (Naqvi et al., Science 315: 531–534, 2007). Yet, there is little …

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