Mitochondrial respiration and dynamics of in vivo neural stem cells

S Petridi, D Dubal, R Rikhy… - Development, 2022 - journals.biologists.com
Neural stem cells (NSCs) in the developing and adult brain undergo many different
transitions, tightly regulated by extrinsic and intrinsic factors. While the role of signalling …

The mitochondrial ribosomal protein mRpL4 regulates Notch signaling

D Mo, C Liu, Y Chen, X Cheng, J Shen, L Zhao… - EMBO …, 2023 - embopress.org
Mitochondrial ribosomal proteins (MRPs) assemble as specialized ribosome to synthesize
mtDNA‐encoded proteins, which are essential for mitochondrial bioenergetic and metabolic …

Drugs targeting TGF-β/Notch interaction attenuate hypertrophic scar formation by optic atrophy 1-mediated mitochondrial fusion

D Huo, X Bi, J Zeng, D Dai, X Dong - Molecular and Cellular Biochemistry, 2024 - Springer
Hypertrophic scar (HS) formation is a cutaneous fibroproliferative disease that occurs after
skin injuries and results in severe functional and esthetic disability. To date, few drugs have …

The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the …

D Jagečić, DJ Petrović, I Šimunić, J Isaković, D Mitrečić - Brain Sciences, 2023 - mdpi.com
Perinatal brain damage, one of the most common causes of lifelong impairment, is
predominantly caused by a lack of oxygen and glucose during early development. These …

[HTML][HTML] Lactobacillus salivarius metabolite succinate enhances chicken intestinal stem cell activities via the SUCNR1-mitochondria axis

D Luo, M Zou, X Rao, M Wei, L Zhang, Y Hua, L Yu… - Poultry Science, 2025 - Elsevier
The activity of intestinal stem cells (ISCs) can be modulated by Lactobacillus, which
subsequently affects the mucosal absorptive capacity. However, the underlying mechanisms …

Lineage-specific changes in mitochondrial properties during neural stem cell differentiation

R Soares, DM Lourenço, IF Mota… - Life Science …, 2024 - life-science-alliance.org
Neural stem cells (NSCs) reside in discrete regions of the adult mammalian brain where
they can differentiate into neurons, astrocytes, and oligodendrocytes. Several studies …

Control of mitochondrial dynamics by dPGC1 limits Yorkie-induced oncogenic growth in Drosophila

WQG Sew, Z Li, LJ Rasmussen, H Herranz - bioRxiv, 2024 - biorxiv.org
Mitochondrial function and dynamics are crucial for maintaining cellular homeostasis and
overall health. Disruptions in these processes can lead to various diseases, including …

Mitochondrial morphology dynamics and ROS regulate apical polarity and differentiation in Drosophila follicle cells

B Uttekar, RK Verma, D Tomer, R Rikhy - Development, 2024 - journals.biologists.com
Mitochondrial morphology dynamics regulate signaling pathways during epithelial cell
formation and differentiation. The mitochondrial fission protein Drp1 affects the appropriate …

Drp1-JNK knockdown mitigates Scribble loss induced cell proliferation, metastasis and lethality phenotypes in Drosophila

J Singh, S Srikrishna - bioRxiv, 2024 - biorxiv.org
Mitochondrial dynamics are emerging as master regulators for targeting several types of
cancers, including breast cancer, cervical cancer, and hepatocellular carcinoma, for …

Rescue of Neurodegenerative Models in Drosophila melanogaster and Conservation of Metabolic and Degradative Regulation by Heparan Sulfate in Mammalian …

N Schultheis - 2025 - etda.libraries.psu.edu
Alzheimer's Disease (AD) is characterized by protein aggregates, mitochondrial dysfunction,
autophagy inhibition, and lipid accumulation. Other neurodegenerative diseases such as …