Reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-
weight thiol in mammalian cells. It is formed in a two-step enzymatic process including, first …

Incidences of breast cancer, type 2 diabetes, and metabolic syndrome have increased over
the past decades with the obesity epidemic, especially in industrialized countries. Insulin …

Purpose: There has been a marked increase in testosterone prescriptions in the past
decade resulting in a growing need to give practicing clinicians proper guidance on the …

Several studies suggest that type 2 diabetes mellitus (T2DM) is often associated with male
hypogonadism. Despite the well‐known link, the role of testosterone replacement therapy …

Objective: Hyperglycemia is considered a primary cause of diabetic vascular complications
and is associated with oxidative stress, impaired trace element and lipid metabolism as well …

Background Alzheimer's disease (AD) is the commonest cause of dementia, with
approximately 5 million new cases occurring annually. Despite decades of research, its …

High‐fat feeding in rodents leads to metabolic abnormalities mimicking the human metabolic
syndrome, including obesity and insulin resistance. These metabolic diseases are …

A multitude of studies in experimental animals, together with clinical data, provide evidence
that increased production of ROS (reactive oxygen species) are involved in the development …

The poultry ovary is used as a classic model to study ovarian biology and ovarian cancer.
Stress factors induced oxidative stress to cause follicle atresia, which may be a fundamental …

Edaravone was originally developed as a potent free radical scavenger, and has been
widely used to treat acute ischemic stroke in Japan since 2001. Free radicals play an …