Insights and implications of sexual dimorphism in osteoporosis

YY Zhang, N Xie, XD Sun, EC Nice, YC Liou, C Huang… - Bone research, 2024 - nature.com
Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

The Role of Breast Cancer Cells in Bone Metastasis: Suitable Seeds for Nourishing Soil

Y Wang, Y Hu, M Wang, M Wang, Y Xu - Current Osteoporosis Reports, 2024 - Springer
Abstract Purpose of Review The purpose of this review was to describe the characteristics of
breast cancer cells prone to developing bone metastasis and determine how they are …

Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair

D Saul, ML Doolittle, JL Rowsey… - The Journal of …, 2024 - Am Soc Clin Investig
Cells expressing features of senescence, including upregulation of p21 and p16, appear
transiently following tissue injury, yet the properties of these cells or how they contrast with …

[HTML][HTML] Roles of Sp7 in osteoblasts for the proliferation, differentiation, and osteocyte process formation

Q Jiang, K Nagano, T Moriishi, H Komori… - Journal of Orthopaedic …, 2024 - Elsevier
Background Zinc finger-containing transcription factor Osterix/Specificity protein-7 (Sp7) is
an essential transcription factor for osteoblast differentiation. However, its functions in …

[HTML][HTML] Schnurri-3 controls osteogenic fate of Adipoq-lineage progenitors in bone marrow

Z Li, X Zeng, B Shi, J Han, Z Wu, X Chen… - Journal of Orthopaedic …, 2024 - Elsevier
Background Recently, the osteogenic potential of Adiponectin-labeled adipogenic lineage
progenitors (Adipoq-lineage progenitors) in bone marrow has been observed to support …

Skeletal stem cells in bone development, homeostasis, and disease

G Yuan, X Lin, Y Liu, MB Greenblatt, R Xu - Protein & Cell, 2024 - academic.oup.com
Tissue-resident stem cells are essential for development and repair, and in the skeleton this
function is fulfilled by recently identified skeletal stem cells (SSCs). However, recent work …

Skeletal stem and progenitor cells in bone development and repair

D Trompet, S Melis, AS Chagin… - Journal of Bone and …, 2024 - academic.oup.com
Bone development, growth, and repair are complex processes involving various cell types
and interactions, with central roles played by skeletal stem and progenitor cells. Recent …

[HTML][HTML] Skeletal stem-cell therapy: challenge meets opportunity

W Cheng, J Huang, N Li, R Xu - The Lancet, 2024 - thelancet.com
The prevalence of skeletal diseases (eg, osteoporosis) increases with age, resulting in pain
and loss of mobility and imposing a major social and economic burden on healthcare …

Stem cells provide clues to why vertebrae attract tumour cells

G Carmeliet - 2023 - nature.com
Stem cells provide clues to why vertebrae attract tumour cells Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

[HTML][HTML] The osteoblast in regulation of tumor cell dormancy and bone metastasis

J Zarrer, H Taipaleenmäki - Journal of Bone Oncology, 2024 - Elsevier
Breast and prostate cancer are among the most common malignancies worldwide. After
treatment of the primary tumor, distant metastases often occur after a long disease-free …