Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …

Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Neutrophils accumulate in solid tumors, and their abundance correlates with poor prognosis.
Neutrophils are not homogeneous, however, and could play different roles in cancer …

In recent years, neutrophils have attracted increasing attention because of their cancer-
promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic …

Non-small cell lung cancer (NSCLC) is characterized by molecular heterogeneity with
diverse immune cell infiltration patterns, which has been linked to therapy sensitivity and …

Cancer vaccines aim to direct the immune system to eradicate cancer cells. Here we review
the essential immunologic concepts underpinning natural immunity and highlight the …

FDA-approved anti–PD-L1 monoclonal antibodies (mAbs) bear the IgG1 isotype, whose
scaffolds are either wild-type (eg, avelumab) or Fc-mutated and lacking Fcγ receptor (FcγR) …

Research on tumor‐associated neutrophils (TAN) currently surges because of the well‐
documented strong clinical relevance of tumor‐infiltrating neutrophils. This relevance is …

Neutrophils, the most abundant and efficient defenders against pathogens, exert opposing
functions across cancer types. However, given their short half-life, it remains challenging to …

Neutrophils are the most abundant circulating leukocytes in humans and the first immune
cells recruited at the site of inflammation. Classically perceived as short-lived effector cells …