Recent structural studies of receptor tyrosine kinases (RTKs) have revealed unexpected
diversity in the mechanisms of their activation by growth factor ligands. Strategies for …

Endocytosis entails selective packaging of cell-surface proteins, such as receptors for
cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Detection and quantification of fluorescently labeled molecules in subcellular compartments
is a key step in the analysis of many cell biological processes. Pixel-wise colocalization …

The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development
and progression of cancer; however, therapeutics targeting it have had disappointing results …

Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel development
by activating 3 receptor tyrosine kinases (RTKs), VEGFR-1,-2, and-3, and by binding to …

All the information to make a complete, fully functional living organism is encoded within the
genome of the fertilized oocyte. How is this genetic code translated into the vast array of …

Multivesicular bodies (MVBs) are intracellular endosomal organelles characterized by
multiple internal vesicles that are enclosed within a single outer membrane. MVBs were …

In recent years, nanoparticulate-mediated drug delivery research has examined a full
spectrum of nanoparticles that can be used in diagnostic and therapeutic cancer …

Insulin and insulin-like growth factor (IGF) receptors utilize common phosphoinositide 3-
kinase/Akt and Ras/extracellular signal-regulated kinase signaling pathways to mediate a …