[HTML][HTML] Cellulose based polymers in development of amorphous solid dispersions

RB Chavan, S Rathi, VGSS Jyothi… - Asian journal of …, 2019 - Elsevier
Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid
dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid …

Advances in polymer design for enhancing oral drug solubility and delivery

JM Ting, WW Porter III, JM Mecca, FS Bates… - Bioconjugate …, 2018 - ACS Publications
Synthetic polymers have enabled amorphous solid dispersions (ASDs) to emerge as an oral
delivery strategy for overcoming poor drug solubility in aqueous environments. Modern ASD …

Recent advances in understanding the micro-and nanoscale phenomena of amorphous solid dispersions

RG Ricarte, NJ Van Zee, Z Li, LM Johnson… - Molecular …, 2019 - ACS Publications
Many pharmaceutical drugs in the marketplace and discovery pipeline suffer from poor
aqueous solubility, thereby limiting their effectiveness for oral delivery. The use of an …

Polymeric nanomedicines for poorly soluble drugs in oral delivery systems: An update

X Ma, RO Williams III - Journal of pharmaceutical investigation, 2018 - Springer
The field of nanomedicine offers promising new drug delivery systems with enhanced
properties. The literature has reported on the development of various nanomedicines that …

Supersaturation and phase behavior during dissolution of amorphous solid dispersions

Y Kong, W Wang, C Wang, L Li, D Peng… - International Journal of …, 2023 - Elsevier
Amorphous solid dispersion (ASD) is a promising strategy to enhance solubility and
bioavailability of poorly water-soluble drugs. Due to higher free energy of ASD …

Drug-rich phases induced by amorphous solid dispersion: arbitrary or intentional goal in oral drug delivery?

K Qian, L Stella, DS Jones, GP Andrews, H Du, Y Tian - Pharmaceutics, 2021 - mdpi.com
Among many methods to mitigate the solubility limitations of drug compounds, amorphous
solid dispersion (ASD) is considered to be one of the most promising strategies to enhance …

A mechanistic review on the dissolution phase behavior and supersaturation stabilization of amorphous solid dispersions

P Ashwathy, AT Anto, MS Sudheesh - Drug Development and …, 2021 - Taylor & Francis
Amorphous solid dispersion (ASD) technology is an attractive formulation approach for
poorly soluble drugs because of the supersaturated state acquired during its dissolution …

Polymer nanogels as reservoirs to inhibit hydrophobic drug crystallization

Z Li, NJ Van Zee, FS Bates, TP Lodge - Acs Nano, 2019 - ACS Publications
The effects of cross-link density and composition on the loading and in vitro dissolution of
the drug phenytoin as amorphous solid dispersions in emulsion polymerized poly (N …

Control drug release behavior by highly stable and pH sensitive poly (N-vinylpyrrolidone)-block-poly (4-vinylpyridine) copolymer micelles

AK Mishra, J Lim, J Lee, S Park, Y Seo, H Hwang… - Polymer, 2021 - Elsevier
Abstract pH sensitivity and stable micelles are necessary for targeted and sustainable
anticancer drug delivery to reduce toxicity. Also, nanocarriers should show high drug …

Cryo-TEM and AFM observation of the time-dependent evolution of amorphous probucol nanoparticles formed by the aqueous dispersion of ternary solid dispersions

Z Zhao, H Katai, K Higashi, K Ueda… - Molecular …, 2019 - ACS Publications
In this study, the time-dependent evolution of amorphous probucol nanoparticles was
characterized by cryogenic transmission electron microscopy (cryo-TEM) and atomic force …