Synthetic polymers have enabled amorphous solid dispersions (ASDs) to emerge as an oral delivery strategy for overcoming poor drug solubility in aqueous environments. Modern ASD …
RG Ricarte, NJ Van Zee, Z Li, LM Johnson… - Molecular …, 2019 - ACS Publications
Many pharmaceutical drugs in the marketplace and discovery pipeline suffer from poor aqueous solubility, thereby limiting their effectiveness for oral delivery. The use of an …
X Ma, RO Williams III - Journal of pharmaceutical investigation, 2018 - Springer
The field of nanomedicine offers promising new drug delivery systems with enhanced properties. The literature has reported on the development of various nanomedicines that …
Y Kong, W Wang, C Wang, L Li, D Peng… - International Journal of …, 2023 - Elsevier
Amorphous solid dispersion (ASD) is a promising strategy to enhance solubility and bioavailability of poorly water-soluble drugs. Due to higher free energy of ASD …
Among many methods to mitigate the solubility limitations of drug compounds, amorphous solid dispersion (ASD) is considered to be one of the most promising strategies to enhance …
P Ashwathy, AT Anto, MS Sudheesh - Drug Development and …, 2021 - Taylor & Francis
Amorphous solid dispersion (ASD) technology is an attractive formulation approach for poorly soluble drugs because of the supersaturated state acquired during its dissolution …
The effects of cross-link density and composition on the loading and in vitro dissolution of the drug phenytoin as amorphous solid dispersions in emulsion polymerized poly (N …
AK Mishra, J Lim, J Lee, S Park, Y Seo, H Hwang… - Polymer, 2021 - Elsevier
Abstract pH sensitivity and stable micelles are necessary for targeted and sustainable anticancer drug delivery to reduce toxicity. Also, nanocarriers should show high drug …
Z Zhao, H Katai, K Higashi, K Ueda… - Molecular …, 2019 - ACS Publications
In this study, the time-dependent evolution of amorphous probucol nanoparticles was characterized by cryogenic transmission electron microscopy (cryo-TEM) and atomic force …