The incorporation of a synthetic, catalytically competent metallocofactor into a protein
scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

Many efforts are being made in the design and engineering of metalloenzymes with catalytic
properties fulfilling the needs of practical applications. Progress in this field has recently …

Here we report the de novo design and NMR structure of a four-helical bundle di-iron protein
with phenol oxidase activity. The introduction of the cofactor-binding and phenol-binding …

Hydrogenase enzymes use first-row transition metals to interconvert H2 with protons and
electrons, reactions that are important for the storage and recovery of energy from …

Metalloenzymes efficiently catalyze some of the most important and difficult reactions in
nature. For many years, coordination chemists have effectively used small molecule models …

Chemists have long been fascinated by metalloenzymes and their chemistry. Because
enzymes are essential for biological processes and to life itself, they present a key to …

De novo proteins provide a unique opportunity to investigate the structure–function
relationships of metalloproteins in a minimal, well-defined and controlled scaffold. Here, we …

Artificial metalloproteins (ArMs) have recently gained significant interest due to their
potential to address issues in a broad scope of applications, including biocatalysis …

A single polypeptide chain may provide an astronomical number of conformers. Nature
selected only a trivial number of them through evolution, composing an alphabet of …