Large-conductance Ca2+-and voltage-activated K+ (BK) channels play many physiological
roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion …

Abstract High-conductance,'big'potassium (BK) channels encoded by the Slo gene family
are among the largest and most complex of the extended family of potassium channels. The …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Large conductance, Ca 2+-activated potassium (BK) channels are widely expressed
throughout the animal kingdom and play important roles in many physiological processes …

Rapid chloride permeation through the cystic fibrosis transmembrane conductance regulator
(CFTR) Cl− channel is dependent on the presence of fixed positive charges in the …

Proteins possess a complex and dynamic structure, which is influenced by external signals
and may change as they perform their biological functions. We present an optical approach …

Many different ion channel pores are thought to have charged amino acid residues clustered
around their entrances. The so-called surface charges contributed by these residues can …

The high conductance voltage‐and Ca2+‐activated K+ channel is one of the most broadly
expressed channels in mammals. This channel is named BK for 'big K'because of its single …

Multi-modal regulation of Slo1 channels by membrane voltage, intracellular calcium, and
auxiliary subunits enables its pleiotropic physiological functions. Our understanding of how …

Large conductance voltage-and Ca2+-activated K+ (BKCa) channels regulate important
physiological processes such as neurotransmitter release and vascular tone. BKCa …