[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

[HTML][HTML] Epidemiology of osteoarthritis

KD Allen, LM Thoma, YM Golightly - Osteoarthritis and cartilage, 2022 - Elsevier
Objective To summarize the current state of the evidence regarding osteoarthritis (OA)
prevalence, incidence and risk factors at the person-level and joint-level. Design This was a …

Prevalence trends of site‐specific osteoarthritis from 1990 to 2019: findings from the global burden of disease study 2019

H Long, Q Liu, H Yin, K Wang, N Diao… - Arthritis & …, 2022 - Wiley Online Library
Objective To estimate systematic and anatomic site–specific age‐standardized prevalence
rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and …

[HTML][HTML] Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies

A Cui, H Li, D Wang, J Zhong, Y Chen, H Lu - EClinicalMedicine, 2020 - thelancet.com
Background Knee osteoarthritis (OA) is a major cause of disability in the elderly, however,
there are few studies to estimate the global prevalence, incidence, and risk factors of knee …

Early-stage symptomatic osteoarthritis of the knee—time for action

A Mahmoudian, LS Lohmander, A Mobasheri… - Nature Reviews …, 2021 - nature.com
Osteoarthritis (OA) remains the most challenging arthritic disorder, with a high burden of
disease and no available disease-modifying treatments. Symptomatic early-stage OA of the …

[HTML][HTML] Knee osteoarthritis: epidemiology, pathogenesis, and mesenchymal stem cells: what else is new? An update

R Giorgino, D Albano, S Fusco, GM Peretti… - International journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a chronic disease and the most common orthopedic disorder. A vast
majority of the social OA burden is related to hips and knees. The prevalence of knee OA …

[HTML][HTML] Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021

JD Steinmetz, GT Culbreth, LM Haile… - The Lancet …, 2023 - thelancet.com
Background Osteoarthritis is the most common form of arthritis in adults, characterised by
chronic pain and loss of mobility. Osteoarthritis most frequently occurs after age 40 years …

Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines

NK Arden, TA Perry, RR Bannuru, O Bruyère… - Nature Reviews …, 2021 - nature.com
Knee osteoarthritis (OA) is a heterogeneous disease associated with substantial effects on
quality of life, and its clinical management is difficult. Among the several available guidelines …

Emerging pharmaceutical therapies for osteoarthritis

A Latourte, M Kloppenburg, P Richette - Nature Reviews Rheumatology, 2020 - nature.com
The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …

Prevalence, deaths, and disability‐adjusted life years due to musculoskeletal disorders for 195 countries and territories 1990–2017

S Safiri, AA Kolahi, M Cross, C Hill… - Arthritis & …, 2021 - Wiley Online Library
Objective To report the levels and trends of prevalence, deaths, and disability‐adjusted life
years (DALYs) due to musculoskeletal disorders, categorized as low back pain, neck pain …