Phosphoinositide lipids play a key role in cellular physiology, participating in a wide array of
cellular processes. Consequently, mutation of phosphoinositide‐metabolizing enzymes is …

The greatest challenge of 21st century biology is to fully understand mechanisms of disease
to drive new approaches and medical innovation. Parallel to this is the huge biomedical …

Plasma membrane proteins are essential molecules in the cell which mediate interactions
with the exterior milieu, thus representing key drug targets for present pharma. Not …

Cellular control of vesicle biology and trafficking is critical for cell viability, with disruption of
these pathways within the cells of the central nervous system resulting in neurodegeneration …

Four P4-ATPase flippase genes, VdDrs2, VdNeo1, VdP4-4, and VdDnf1 were identified in
Verticillium dahliae, one of the most devastating phytopathogenic fungi in the world. Knock …

The genetic determinants of many diseases, including monogenic diseases and cancers,
have been identified; nevertheless, targeted therapy remains elusive for most. High …

Over the past years a growing number of studies highlighted the pivotal role of intracellular
trafficking in cell physiology. Among the distinct transport itineraries connecting the …

Specificity of small molecules for their target molecule in the cell is critical to determine their
effective use as biologics and therapeutics. Small molecule inhibitors of clathrin endocytosis …

Introduction: Membrane trafficking processes are essential for cell viability and basic
functions, as well as for interactions between the cell interior and the surrounding …

Introduction: Membrane trafficking processes are essential for cell viability and basic
functions, as well as for interactions between the cell interior and the surrounding …