Structural insights into SARS-CoV-2 proteins
The unprecedented scale of the ongoing COVID-19 pandemic has catalyzed an intense
effort of the global scientific community to unravel different aspects of the disease in a short …
effort of the global scientific community to unravel different aspects of the disease in a short …
SARS‐CoV‐2, the pandemic coronavirus: Molecular and structural insights
SB Kadam, GS Sukhramani, P Bishnoi… - Journal of basic …, 2021 - Wiley Online Library
The outbreak of a novel coronavirus associated with acute respiratory disease, called
COVID‐19, marked the introduction of the third spillover of an animal coronavirus (CoV) to …
COVID‐19, marked the introduction of the third spillover of an animal coronavirus (CoV) to …
Structural characterization of SARS-CoV-2: where we are, and where we need to be
G Mariano, RJ Farthing, SLM Lale-Farjat… - Frontiers in molecular …, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in
humans in almost every country, causing the disease COVID-19. Since the start of the …
humans in almost every country, causing the disease COVID-19. Since the start of the …
COVID-19 and SARS-CoV-2. Modeling the present, looking at the future
E Estrada - Physics reports, 2020 - Elsevier
Abstract Since December 2019 the Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) has produced an outbreak of pulmonary disease which has soon become a …
(SARS-CoV-2) has produced an outbreak of pulmonary disease which has soon become a …
Structure and function of major SARS-CoV-2 and SARS-CoV proteins
SARS-CoV-2 virus, the causative agent of COVID-19 pandemic, has a genomic organization
consisting of 16 nonstructural proteins (nsps), 4 structural proteins, and 9 accessory …
consisting of 16 nonstructural proteins (nsps), 4 structural proteins, and 9 accessory …
The enzymatic activity of the nsp14 exoribonuclease is critical for replication of MERS-CoV and SARS-CoV-2
NS Ogando, JC Zevenhoven-Dobbe… - Journal of …, 2020 - Am Soc Microbiol
Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …
Supercomputer-based ensemble docking drug discovery pipeline with application to COVID-19
We present a supercomputer-driven pipeline for in silico drug discovery using enhanced
sampling molecular dynamics (MD) and ensemble docking. Ensemble docking makes use …
sampling molecular dynamics (MD) and ensemble docking. Ensemble docking makes use …
RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global pandemic. Although …
syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global pandemic. Although …
The deregulated immune reaction and cytokines release storm (CRS) in COVID-19 disease
R Pasrija, M Naime - International Immunopharmacology, 2021 - Elsevier
COVID-19 caused by the SARS-CoV-2 virus, accompanies an unprecedented spike in
cytokines levels termed cytokines release syndrome (CRS), in critically ill patients. Clinicians …
cytokines levels termed cytokines release syndrome (CRS), in critically ill patients. Clinicians …
Nsp16 shields SARS–CoV‐2 from efficient MDA5 sensing and IFIT1‐mediated restriction
A Russ, S Wittmann, Y Tsukamoto, A Herrmann… - EMBO …, 2022 - embopress.org
Methylation of the mRNA 5′ cap by cellular methyltransferases enables efficient translation
and avoids recognition by innate immune factors. Coronaviruses encode viral 2′‐O …
and avoids recognition by innate immune factors. Coronaviruses encode viral 2′‐O …