Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission
Background The 8‐aminoquinoline (8AQ) drugs act on Plasmodium falciparum
gametocytes, which transmit malaria from infected people to mosquitoes. In 2012, the World …
gametocytes, which transmit malaria from infected people to mosquitoes. In 2012, the World …
Dihydroartemisinin‐piperaquine for treating uncomplicated Plasmodium falciparum malaria
Abstract Background The World Health Organization (WHO) recommends Artemisinin‐
based Combination Therapy (ACT) for treating uncomplicated Plasmodium falciparum …
based Combination Therapy (ACT) for treating uncomplicated Plasmodium falciparum …
The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: a cluster randomised trial
L Von Seidlein, TJ Peto, J Landier, TN Nguyen… - PLoS …, 2019 - journals.plos.org
Background The emergence and spread of multidrug-resistant Plasmodium falciparum in
the Greater Mekong Subregion (GMS) threatens global malaria elimination efforts. Mass …
the Greater Mekong Subregion (GMS) threatens global malaria elimination efforts. Mass …
Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled …
Background Primaquine and methylene blue are gametocytocidal compounds that could
prevent Plasmodium falciparum transmission to mosquitoes. We aimed to assess the …
prevent Plasmodium falciparum transmission to mosquitoes. We aimed to assess the …
A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection
S D'Alessandro, F Silvestrini… - Journal of …, 2013 - academic.oup.com
Objectives Plasmodium gametocytes, responsible for malaria parasite transmission from
humans to mosquitoes, represent a crucial target for new antimalarial drugs to achieve …
humans to mosquitoes, represent a crucial target for new antimalarial drugs to achieve …
Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double …
AC Eziefula, T Bousema, S Yeung… - The Lancet infectious …, 2014 - thelancet.com
Background Primaquine is the only available drug that clears mature Plasmodium
falciparum gametocytes in infected human hosts, thereby preventing transmission of malaria …
falciparum gametocytes in infected human hosts, thereby preventing transmission of malaria …
Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial
A Dicko, JM Brown, H Diawara, I Baber… - The Lancet Infectious …, 2016 - thelancet.com
Background Single low doses of primaquine, when added to artemisinin-based combination
therapy, might prevent transmission of Plasmodium falciparum malaria to mosquitoes. We …
therapy, might prevent transmission of Plasmodium falciparum malaria to mosquitoes. We …
Fighting fire with fire: mass antimalarial drug administrations in an era of antimalarial resistance
L Von Seidlein, A Dondorp - Expert review of anti-infective therapy, 2015 - Taylor & Francis
The emergence and spread of antimalarial resistance has been a major liability for malaria
control. The spread of chloroquine-resistant Plasmodium falciparum strains had catastrophic …
control. The spread of chloroquine-resistant Plasmodium falciparum strains had catastrophic …
Risk of sudden unexplained death after use of dihydroartemisinin–piperaquine for malaria: a systematic review and Bayesian meta-analysis
XHS Chan, YN Win, LJ Mawer, JY Tan… - The Lancet Infectious …, 2018 - thelancet.com
Background Dihydroartemisinin–piperaquine is an effective and well tolerated artemisinin-
based combination therapy that has been assessed extensively for the prevention and …
based combination therapy that has been assessed extensively for the prevention and …
Identification of the asymptomatic Plasmodium falciparum and Plasmodium vivax gametocyte reservoir under different transmission intensities
C Koepfli, W Nguitragool, ACG de Almeida… - PLoS neglected …, 2021 - journals.plos.org
Background Understanding epidemiological variables affecting gametocyte carriage and
density is essential to design interventions that most effectively reduce malaria human-to …
density is essential to design interventions that most effectively reduce malaria human-to …