Cytokine‐and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy
Colorectal cancer (CRC) is a predominant life‐threatening cancer, with liver and peritoneal
metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor …
metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor …
[HTML][HTML] Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance
AE Tuomisto, MJ Mäkinen… - World journal of …, 2019 - ncbi.nlm.nih.gov
Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-
40% of colorectal cancer patients. The hallmarks of systemic inflammation include an …
40% of colorectal cancer patients. The hallmarks of systemic inflammation include an …
[HTML][HTML] Genetic and epigenetic characteristics of inflammatory bowel Disease–Associated colorectal cancer
Background & Aims Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory
disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC …
disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC …
Development of PARP and immune-checkpoint inhibitor combinations
RA Stewart, PG Pilié, TA Yap - Cancer research, 2018 - AACR
PARP inhibitors drive increased DNA damage, particularly in tumors with existing defects in
DNA repair. This damage not only promotes immune priming through a range of molecular …
DNA repair. This damage not only promotes immune priming through a range of molecular …
Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine
Immunotherapy strategies targeting immune checkpoints such as the CTLA4 and CD274
(programmed cell death 1 ligand 1, PD-L1)/PDCD1 (programmed cell death 1, PD-1) T-cell …
(programmed cell death 1 ligand 1, PD-L1)/PDCD1 (programmed cell death 1, PD-1) T-cell …
PD‐1/PD‐L1‐dependent immune response in colorectal cancer
Colorectal cancer (CRC) is still considered as the third most frequent cancer in the world.
Microsatellite instability (MSI), inflammation, and microRNAs have been demonstrated as …
Microsatellite instability (MSI), inflammation, and microRNAs have been demonstrated as …
An update on colorectal cancer microenvironment, epigenetic and immunotherapy
K Jin, C Ren, Y Liu, H Lan, Z Wang - International immunopharmacology, 2020 - Elsevier
Colorectal cancer (CRC) is considered as the second most common cancer worldwide. For
the past few years, the role of immunotherapy has been extensively studied and it has been …
the past few years, the role of immunotherapy has been extensively studied and it has been …
[HTML][HTML] CMTM6 and PD-L1 coexpression is associated with an active immune microenvironment and a favorable prognosis in colorectal cancer
QH Peng, CH Wang, HM Chen, RX Zhang… - … for Immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6), a
programmed death-ligand 1 (PD-L1) regulator, is widely expressed in various tumors and …
programmed death-ligand 1 (PD-L1) regulator, is widely expressed in various tumors and …
Microsatellite instability in colorectal cancers: carcinogenesis, neo-antigens, immuno-resistance and emerging therapies
V Randrian, C Evrard, D Tougeron - Cancers, 2021 - mdpi.com
Simple Summary A deficient mismatch repair system (dMMR) results in microsatellite
instability (MSI). The MSI status of a tumor predicts the response to immune checkpoint …
instability (MSI). The MSI status of a tumor predicts the response to immune checkpoint …
Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases
Background The pathogenic effect of colorectal tumor molecular features may be influenced
by several factors, including those related to microbiota, inflammation, metabolism, and …
by several factors, including those related to microbiota, inflammation, metabolism, and …