Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …

Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in
any of the five subunits of the NADPH oxidase complex responsible for the respiratory burst …

Background. Chronic granulomatous disease (CGD) is due to defective nicotinamide
adenine dinucleotide phosphate oxidase activity and characterized by recurrent infections …

Background Primary immunodeficiency diseases (PIDDs) are clinically and genetically
heterogeneous disorders thus far associated with mutations in more than 300 genes. The …

When exposed to certain stimuli, phagocytes (including neutrophils, macrophages and
eosinophils) undergo marked changes in the way they handle oxygen. Firstly, their rate of …

Background Chronic granulomatous disease (CGD) is a rare primary immunodeficiency
disorder of phagocytes resulting in impaired killing of bacteria and fungi. A mutation in one …

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by
defects in the genes encoding any of the NADPH oxidase components responsible for the …

Primary immunodeficiency diseases (PIDs) are a group of inherited disorders, characterized
by defects of the immune system predisposing individuals to variety of manifestations …

Context: Inbreeding increases the level of homozygotes for autosomal recessive disorders
and is the major objective in clinical studies. The prevalence of consanguinity and the …

Chronic granulomatous disease (CGD) is an innate immunodeficiency with a genetic defect
of the nicotinamide adenosine dinucleotide phosphate, reduced, oxidase components. This …