Liquid biopsy: from discovery to clinical application
C Alix-Panabières, K Pantel - Cancer discovery, 2021 - AACR
Over the past 10 years, circulating tumor cells (CTC) and circulating tumor DNA (ctDNA)
have received enormous attention as new biomarkers and subjects of translational research …
have received enormous attention as new biomarkers and subjects of translational research …
Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy
ZF Lim, PC Ma - Journal of hematology & oncology, 2019 - Springer
The biggest hurdle to targeted cancer therapy is the inevitable emergence of drug
resistance. Tumor cells employ different mechanisms to resist the targeting agent. Most …
resistance. Tumor cells employ different mechanisms to resist the targeting agent. Most …
Phenotype plasticity as enabler of melanoma progression and therapy resistance
I Arozarena, C Wellbrock - Nature Reviews Cancer, 2019 - nature.com
Malignant melanoma is notorious for its inter-and intratumour heterogeneity, based on
transcriptionally distinct melanoma cell phenotypes. It is thought that these distinct …
transcriptionally distinct melanoma cell phenotypes. It is thought that these distinct …
The lipogenic regulator SREBP2 induces transferrin in circulating melanoma cells and suppresses ferroptosis
Circulating tumor cells (CTC) are shed by cancer into the bloodstream, where a viable
subset overcomes oxidative stress to initiate metastasis. We show that single CTCs from …
subset overcomes oxidative stress to initiate metastasis. We show that single CTCs from …
Tracking cancer progression: From circulating tumor cells to metastasis
F Castro-Giner, N Aceto - Genome medicine, 2020 - Springer
The analysis of circulating tumor cells (CTCs) is an outstanding tool to provide insights into
the biology of metastatic cancers, to monitor disease progression and with potential for use …
the biology of metastatic cancers, to monitor disease progression and with potential for use …
Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells
Circulating tumor cell (CTC)-based liquid biopsies provide unique opportunities for cancer
diagnostics, treatment selection, and response monitoring, but even with advanced …
diagnostics, treatment selection, and response monitoring, but even with advanced …
Liquid biopsies: applications for cancer diagnosis and monitoring
I Martins, IP Ribeiro, J Jorge, AC Gonçalves… - Genes, 2021 - mdpi.com
The minimally—or non-invasive detection of circulating tumor-derived components in
biofluids, such as blood, liquid biopsy is a revolutionary approach with significant potential …
biofluids, such as blood, liquid biopsy is a revolutionary approach with significant potential …
Combining immune checkpoint inhibitors: established and emerging targets and strategies to improve outcomes in melanoma
DO Khair, HJ Bax, S Mele, S Crescioli… - Frontiers in …, 2019 - frontiersin.org
The immune system employs several checkpoint pathways to regulate responses, maintain
homeostasis and prevent self-reactivity and autoimmunity. Tumor cells can hijack these …
homeostasis and prevent self-reactivity and autoimmunity. Tumor cells can hijack these …
Biomarkers for clinical benefit of immune checkpoint inhibitor treatment—a review from the melanoma perspective and beyond
K Buder-Bakhaya, JC Hassel - Frontiers in immunology, 2018 - frontiersin.org
Background Immune checkpoint inhibition (ICI) with anti-CTLA-4 and/or anti-PD-1
antibodies is standard treatment for metastatic melanoma. Anti-PD-1 (pembrolizumab …
antibodies is standard treatment for metastatic melanoma. Anti-PD-1 (pembrolizumab …
Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment
Cancer immunotherapy has achieved remarkable success over the past decade by
modulating patients' own immune systems and unleashing pre-existing immunity. However …
modulating patients' own immune systems and unleashing pre-existing immunity. However …