The development of precision medicine for the management of metastatic breast cancer is
an appealing concept; however, major scientific and logistical challenges hinder its …

The success of checkpoint blockade therapy against cancer has unequivocally shown that
cancer cells can be effectively recognized by the immune system and eliminated. However …

Alternative splicing provides a major mechanism to generate protein diversity. Increasing
evidence suggests a link of dysregulation of splicing associated with cancer. Genome-wide …

Objective The majority of genes are alternatively spliced and growing evidence suggests
that alternative splicing is modified in cancer and is associated with cancer progression …

Motivation It is a challenging task to discover personalized driver genes that provide crucial
information on disease risk and drug sensitivity for individual patients. However, few …

The rapid accumulation of clinical RNA-seq data sets has provided the opportunity to
associate mRNA isoform variations to clinical outcomes. Here we report a statistical method …

The vitamin D receptor binds the seco-steroid hormone 1, 25 (OH) 2D3 with high affinity and
controls gene programs that include a significant component of the control of serum calcium …

Colorectal cancer (CRC) is a malignant tumor and a major cause of morbidity and mortality
globally. The classic Tumor‑Node‑Metastasis staging system, which currently underlies the …

Breast cancer is very heterogenous and the most common gynaecological cancer, with
various factors affecting its development. While its impact on human lives and national …

Alternative splicing (AS), a major mechanism for the enhancement of transcriptome and
proteome diversity, has been widely demonstrated to be involved in the full spectrum of …