During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

The sialic acid–binding immunoglobulin-like lectin (Siglec)–sialic acid immune axis is an
evolutionarily conserved immunoregulatory pathway that provides a mechanism for …

Carbohydrate-specific antibodies are widespread among all classes of immunoglobulins.
Despite their broad occurrence, little is known about their formation and biological …

In humans, several grams of IgA are secreted every day in the intestinal lumen. While only
one IgA isotype exists in mice, humans secrete IgA1 and IgA2, whose respective relations …

Cockroach sensitization is an important risk factor for the development of asthma. However,
its underlying immune mechanisms and the genetic etiology for differences in allergic …

Abstract Changes in sialic acids in cancer have been observed for many years. In particular,
the increase of sialoglycan density or hypersialylation in tumors has been described. Recent …

We have explored the fundamental biological processes by which complex carbohydrates
expressed on cellular glycoproteins and glycolipids and in secretions of cells promote cell …

Background Commensals induce local IgA responses essential to the induction of tolerance
to gut microbiota, but it remains unclear whether antimicrobiota responses remain confined …

Interactions between glycans and glycan binding proteins are essential for numerous
processes in all kingdoms of life. Glycan microarrays are an excellent tool to examine …

Glycans and glycan binding proteins (GBPs or lectins) are essential components in almost
every aspect of immunology. Investigations of the interactions between glycans and GBPs …