In the past few decades, the prevalence of allergic diseases has increased worldwide. Here,
we review the etiology and pathophysiology of allergic diseases, including the role of the …

Mast cells (MCs) are immune cells distributed in many organs and tissues and involved in
the pathogenesis of allergic and inflammatory diseases as a major source of pro …

The pathophysiology of mast cell (MC)-driven disorders is diverse, ranging from localized
reactions to systemic disorders caused by abnormal accumulation and activation in multi …

In the past 10 years, anaphylaxis has grown into its own special area of study within Allergy-
Immunology, both at the bench and at the bedside. This review focuses on some of the most …

Given that mast cells are pivotal contributors to allergic diseases, various allergy treatments
have been developed to inhibit them. Omalizumab, an anti-immunoglobulin E antibody, is a …

Background Mounting evidence supports a mechanistic association between irritable bowel
syndrome (IBS) symptoms and mast cell hyperactivity. Yet, association between IBS and …

The purpose of this focused review is to develop a consolidated hypothesis as to the causes
and mechanisms of central sensitization and a related model for a treatment approach using …

Mast cells are granulocytic immunomodulatory cells with an important role in physiologic
and pathogenic processes due to their location at the junction between the internal and …

Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disturbance, diagnosed
in early childhood. It is associated with varying degrees of dysfunctional communication and …

Integrating clinical parameters and diagnostic test recognition and underlying clonal MC
disease are of utmost importance for a patient-tailored approach. Hereditary alpha …