Mitochondria of all tissues convert various metabolic substrates into two forms of energy:
ATP and heat. Historically, the primary focus of research in mitochondrial bioenergetics was …

Ca 2+ flux across the inner mitochondrial membrane (IMM) regulates cellular bioenergetics,
intra-cellular cytoplasmic Ca 2+ signals, and various cell death pathways. Ca 2+ entry into …

Following the Goldilocks principle, mitochondria size must be" just right." Mitochondria
balance division and fusion to avoid becoming too big or too small. Defects in this balance …

Copper is required for the activity of cytochrome c oxidase (COX), the terminal electron-
accepting complex of the mitochondrial respiratory chain. The likely source of copper used …

Vascular calcification is a serious complication of hyperphosphatemia that causes
cardiovascular morbidity and mortality. Previous studies have reported that plasmalemmal …

The mitochondrial carrier family protein SLC25A3 transports both copper and phosphate in
mammals, yet in Saccharomyces cerevisiae the transport of these substrates is partitioned …

Skin cutaneous melanoma (SKCM) is a skin cancer type characterized by a high degree of
immune cell infiltration. The potential function of lactate, a main metabolic product in the …

The increasing application of next generation sequencing approaches to the analysis of
human exome and whole genome data has enabled the identification of novel variants and …

Intracerebral hemorrhage (ICH) is the second most common subtype of stroke, characterized
by high mortality and a poor prognosis. Despite various treatment methods, there has been …

The opioids are powerful analgesics yet possess contingencies that can lead to opioid‐use
disorder. Chemical probes derived from the opioid alkaloids can provide deeper insight into …