Genomic alterations in thyroid cancer: biological and clinical insights

I Landa, ME Cabanillas - Nature Reviews Endocrinology, 2024 - nature.com
Tumours can arise from thyroid follicular cells if they acquire driver mutations that
constitutively activate the MAPK signalling pathway. In addition, a limited set of additional …

The Effects of Deregulated Ribosomal Biogenesis in Cancer

Y Lu, S Wang, Y Jiao - Biomolecules, 2023 - mdpi.com
Simple Summary Ribosomes are macromolecular complexes responsible for mRNA
translation. When ribosome biogenesis is hyperactive or aberrant or ribosomal factors are …

Structural insight into the multifunctionality of non-stoichiometric BNT ferroelectrics

J Shi, J Wang, F Zhu, W Tian, W Hua, H Fan… - Journal of Materials …, 2024 - pubs.rsc.org
Fascinatingly high saturation polarization and electric-field induced strain make bismuth–
sodium–titanium (BNT) promising alternatives. Interestingly, significantly improved oxide-ion …

Tumor-suppressive activities for pogo transposable element derived with KRAB domain via ribosome biogenesis restriction

Z Tu, MA Bassal, GW Bell, Y Zhang, Y Hu, LM Quintana… - Molecular Cell, 2024 - cell.com
Transposable elements (TEs) are indispensable for human development, with critical
functions in pluripotency and embryogenesis. TE sequences also contribute to human …

Oral administration of Sophora Flavescens-derived exosomes-like nanovesicles carrying CX5461 ameliorates DSS-induced colitis in mice

M Zhang, X Xu, L Su, Y Zeng, J Lin, W Li, Y Zou… - Journal of …, 2024 - Springer
Ulcerative colitis (UC) belongs to chronic inflammatory disease with a relapsing
characterization. Conventional oral drugs of UC are restricted in clinical by premature …

Characterizing genetic alterations related to radioiodine avidity in metastatic thyroid cancer

Z Mu, X Zhang, D Sun, Y Sun, C Shi… - The Journal of …, 2024 - academic.oup.com
Context Patients with differentiated thyroid cancer (DTC) with distant metastasis (DM) are
usually not recognized as radioactive iodine (RAI)-refractory DTC in a timely manner. The …

[HTML][HTML] A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer

PZ Han, WD Ye, PC Yu, LC Tan, X Shi, XF Chen, C He… - JCI insight, 2024 - ncbi.nlm.nih.gov
Both anaplastic thyroid cancer (ATC) and papillary thyroid cancer (PTC) originate from
thyroid follicular epithelial cells, but ATC has a significantly worse prognosis and shows …

TERT promoter mutations in gliomas: Molecular roles in tumorigenesis, metastasis, diagnosis, prognosis, therapeutic targeting, and drug resistance

AK Murugan, S Kannan, AS Alzahrani - Biochimica et Biophysica Acta (BBA …, 2024 - Elsevier
Telomerase reverse transcriptase (TERT), a critical player in cellular immortalization, has
emerged as a focal point of investigation due to its frequent promoter mutations in various …

Emerging therapeutic options for follicular-derived thyroid cancer in the era of immunotherapy

N Turner, S Hamidi, R Ouni, R Rico… - Frontiers in …, 2024 - frontiersin.org
Although most follicular-derived thyroid cancers are well differentiated and have an overall
excellent prognosis following treatment with surgery and radioiodine, management of …

Single-cell and spatial transcriptomics in endocrine research

R Matsumoto, T Yamamoto - Endocrine Journal, 2024 - jstage.jst.go.jp
Accumulating evidence suggests that cellular heterogeneity in organs and cell-cell and
tissue-tissue interactions are crucial for maintaining physical homeostasis and disease …