This paper is intended to give a comprehensive review of light-sheet (LS) microscopy from
an optics perspective. As such, emphasis is placed on the advantages that LS microscope …

The development of multifunctional agents for simultaneous tumor targeting and near
infrared (NIR) fluorescence imaging is expected to have significant impact on future …

Squaraine dyes are a class of organic dyes with strong and narrow absorption bands in the
near-infrared. Despite high molar absorptivities and fluorescence quantum yields, these …

A long-standing goal of biology is to map the behavior of all cells during vertebrate
embryogenesis. We developed digital scanned laser light sheet fluorescence microscopy …

Advances in molecular biology, organic chemistry, and materials science have recently
created several new classes of fluorescent probes for imaging in cell biology. Here we …

The extracellular matrix (ECM) regulates cell behavior by influencing cell proliferation,
survival, shape, migration and differentiation. Far from being a static structure, the ECM is …

Selective plane illumination microscopy (SPIM) and other fluorescence microscopy
techniques in which a focused sheet of light serves to illuminate the sample have become …

Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …

We report that single (or selective) plane illumination microscopy (SPIM), combined with a
new deconvolution algorithm, provides a three-dimensional spatial resolution exceeding …

This paper reviews the rapid advances that have been made in one form of optical biological
imaging in the last decade, namely that of light sheet microscopy. Although the concept was …