DNA replication is spatially and temporally regulated during S phase to execute efficient and
coordinated duplication of entire genome. Various epigenomic mechanisms operate to …

The replication-timing program constitutes a key element of the organization and
coordination of numerous nuclear processes in eukaryotes. This program is established at a …

DNA double-strand breaks (DSBs) can be repaired by several pathways. In eukaryotes, DSB
repair pathway choice occurs at the level of DNA end resection and is controlled by the cell …

During space exploration, space radiation is widely recognized as an inescapable perilous
stressor, owing to its capacity to induce genomic DNA damage and escalate the likelihood of …

B cell lymphopoiesis requires dynamic modulation of the B cell transcriptome for timely
coordination of somatic mutagenesis and DNA repair in progenitor B (pro-B) cells. Here, we …

Replication timing (RT) is a cellular program to coordinate initiation of DNA replication in all
origins within the genome. RIF1 (replication timing regulatory factor 1) is a master regulator …

HeLa cells are a cell line with two unique cellular features: a short-shouldered survival curve
and two peaks of radioresistance during the cell cycle phase, while their underlying …

Rif1 mediates telomere length, DNA replication, and DNA damage responses in budding
yeast. Previous work identified several posttranslational modifications of Rif1, however none …

Some allogeneic stem cell transplantation (allo-SCT) recipients develop therapy-related
myeloid neoplasms (t-MNs) of recipient origin with features including karyotypically …

Timely and accurate genome duplication is essential to maintain genome integrity and cell
survival. DNA replication-associated damage is one of the leading causes of genome …