[HTML][HTML] Physics-informed graph neural network emulation of soft-tissue mechanics

D Dalton, D Husmeier, H Gao - Computer Methods in Applied Mechanics …, 2023 - Elsevier
Modern computational soft-tissue mechanics models have the potential to offer unique,
patient-specific diagnostic insights. The deployment of such models in clinical settings has …

Polygonal surface processing and mesh generation tools for the numerical simulation of the cardiac function

M Fedele, A Quarteroni - International Journal for Numerical …, 2021 - Wiley Online Library
In order to simulate the cardiac function for a patient‐specific geometry, the generation of the
computational mesh is crucially important. In practice, the input is typically a set of …

Computational cardiac physiology for new modelers: Origins, foundations, and future

JT Koivumäki, J Hoffman, MM Maleckar… - Acta …, 2022 - Wiley Online Library
Mathematical models of the cardiovascular system have come a long way since they were
first introduced in the early 19th century. Driven by a rapid development of experimental …

Surrogate models based on machine learning methods for parameter estimation of left ventricular myocardium

L Cai, L Ren, Y Wang, W Xie… - Royal Society open …, 2021 - royalsocietypublishing.org
A long-standing problem at the frontier of biomechanical studies is to develop fast methods
capable of estimating material properties from clinical data. In this paper, we have studied …

Uncertainties in the Analysis of Heart Rate Variability: A Systematic Review

L Lu, T Zhu, D Morelli, A Creagh, Z Liu… - IEEE Reviews in …, 2023 - ieeexplore.ieee.org
Heart rate variability (HRV) is an important metric with a variety of applications in clinical
situations such as cardiovascular diseases, diabetes mellitus, and mental health. HRV data …

[HTML][HTML] Emulation of cardiac mechanics using Graph Neural Networks

D Dalton, H Gao, D Husmeier - Computer Methods in Applied Mechanics …, 2022 - Elsevier
Abstract Recent progress in Graph Neural Networks (GNNs) has allowed the creation of new
methods for surrogate modelling, or emulation, of complex physical systems to a high level …

Enabling forward uncertainty quantification and sensitivity analysis in cardiac electrophysiology by reduced order modeling and machine learning

S Pagani, A Manzoni - International Journal for Numerical …, 2021 - Wiley Online Library
We present a new, computationally efficient framework to perform forward uncertainty
quantification (UQ) in cardiac electrophysiology. We consider the monodomain model to …

Efficient approximation of cardiac mechanics through reduced‐order modeling with deep learning‐based operator approximation

L Cicci, S Fresca, A Manzoni… - International Journal for …, 2024 - Wiley Online Library
Reducing the computational time required by high‐fidelity, full‐order models (FOMs) for the
solution of problems in cardiac mechanics is crucial to allow the translation of patient …

An implementation of patient-specific biventricular mechanics simulations with a deep learning and computational pipeline

R Miller, E Kerfoot, C Mauger, TF Ismail… - Frontiers in …, 2021 - frontiersin.org
Parameterised patient-specific models of the heart enable quantitative analysis of cardiac
function as well as estimation of regional stress and intrinsic tissue stiffness. However, the …

Design and execution of a verification, validation, and uncertainty quantification plan for a numerical model of left ventricular flow after LVAD implantation

A Santiago, C Butakoff, B Eguzkitza… - PLoS computational …, 2022 - journals.plos.org
Background Left ventricular assist devices (LVADs) are implantable pumps that act as a life
support therapy for patients with severe heart failure. Despite improving the survival rate …