TRPC1, Orai1, and STIM1 in SOCE: Friends in tight spaces

IS Ambudkar, LB de Souza, HL Ong - Cell calcium, 2017 - Elsevier
Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of ER-Ca 2+ stores and critically controls the regulation of …

Role of TRPC channels in store-operated calcium entry

HL Ong, LB de Souza, IS Ambudkar - … entry pathways in non-excitable cells, 2016 - Springer
Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of Ca 2+ stores within the endoplasmic reticulum (ER) and contributes …

ORAI calcium channels

M Trebak, JW Putney Jr - Physiology, 2017 - journals.physiology.org
In this review article, we discuss the different gene products and translational variants of
ORAI proteins and their contribution to the makeup of different native calcium-conducting …

Ca2+ signaling and regulation of fluid secretion in salivary gland acinar cells

IS Ambudkar - Cell calcium, 2014 - Elsevier
Neurotransmitter stimulation of plasma membrane receptors stimulates salivary gland fluid
secretion via a complex process that is determined by coordinated temporal and spatial …

Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry

L Albarran, JJ Lopez, NB Amor, FE Martin-Cano… - Scientific reports, 2016 - nature.com
Ca2+ influx by store-operated Ca2+ channels is a major mechanism for intracellular Ca2+
homeostasis and cellular function. Here we present evidence for the dynamic interaction …

STIM2 mediates excessive store-operated calcium entry in patient-specific iPSC-derived neurons modeling a juvenile form of huntington's disease

VA Vigont, DA Grekhnev, OS Lebedeva… - Frontiers in Cell and …, 2021 - frontiersin.org
Huntington's disease (HD) is a severe autosomal-dominant neurodegenerative disorder
caused by a mutation within a gene, encoding huntingtin protein. Here we have used the …

TRP channels as molecular targets to relieve endocrine-related diseases

Y Liu, Y Lyu, H Wang - TRP Channels as Therapeutic Targets, 2024 - Elsevier
Transient receptor potential (TRP) channels are polymodal channels capable of sensing
environmental stimuli, which are widely expressed on the plasma membrane of cells and …

[HTML][HTML] The imprint of salivary secretion in autoimmune disorders and related pathological conditions

KR Bhattarai, R Junjappa, M Handigund, HR Kim… - Autoimmunity …, 2018 - Elsevier
Xerostomia is a state of oral dryness associated with salivary gland dysfunction and is
induced by stress, radiation and chemical therapy, various systemic and autoimmune …

[HTML][HTML] Lipid rafts, KCa/ClCa/Ca2+ channel complexes and EGFR signaling: Novel targets to reduce tumor development by lipids?

M Gueguinou, A Gambade, R Félix, A Chantôme… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Membrane lipid rafts are distinct plasma membrane nanodomains that are enriched with
cholesterol, sphingolipids and gangliosides, with occasional presence of saturated fatty …

Magnesium-induced cell survival is dependent on TRPM7 expression and function

Y Sun, P Sukumaran, BB Singh - Molecular neurobiology, 2020 - Springer
Mg 2+ homeostasis is essential for cell survival and the loss of this regulation has been
associated with many neurodegenerative diseases, including loss of dopaminergic neurons …