The thymus is the main producer of αβ T cells and is, therefore, crucial for a normal immune
system. The intrathymic developmental pathway of human αβ T cells has now been …

The fetus and infant are highly susceptible to viral infections. Several viruses, including
human cytomegalovirus (CMV), cause more severe disease in early life compared with later …

Human embryonic stem cells (hESC) are pluripotent stem cells. A major challenge in the
field of hESC is the establishment of specific differentiation protocols that drives hESC down …

Ets family transcription factors control the expression of a large number of genes in
hematopoietic cells. Here we show strikingly precise differential expression of a subset of …

Mouse CD1. 1 is an MHC class I-like, non-MHC-encoded, surface glycoprotein that can be
recognized by T cells, in particular NK1. 1+ T cells, a subset of αβ T cells with semiinvariant …

Recent studies have identified several populations of progenitor cells in the human thymus.
The hematopoietic precursor activity of these populations has been determined. The most …

Successive Steps In T lymphocyte differentiation and T potential of human stem cells (HSC)
can be tested in the following models:(a) the infusion of cells in NOD‐SCID MICE,(b) the …

Abstract Although CD4+ and CD8+ T cells differ in the strength of their positively selecting
signal, endogenous positively selecting ligands have been identified only for major …

The immune system in early life is regarded as immature. However, the IL-12 family member
IL-23 is highly produced upon TLR stimulation by neonatal DCs. Human adult Vγ9Vδ2 T …

Abstract CD4+ CD8+ double-positive (DP) T cells represent a minor subpopulation of T
lymphocytes found in the periphery of adult rats. In this study, we show that peripheral DP T …