Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA

PG Mullins, DJ McGonigle, RL O'Gorman, NAJ Puts… - Neuroimage, 2014 - Elsevier
There is increasing interest in the use of edited proton magnetic resonance spectroscopy for
the detection of GABA in the human brain. At a recent meeting held at Cardiff University, a …

In vivo magnetic resonance spectroscopy of GABA: a methodological review

NAJ Puts, RAE Edden - Progress in nuclear magnetic resonance …, 2012 - Elsevier
Conclusion MRS has become established as a robust and powerful tool for the investigation
of the inhibitory neurotransmitter GABA. This is a significant success, given the significant …

Preprocessing, analysis and quantification in single‐voxel magnetic resonance spectroscopy: experts' consensus recommendations

J Near, AD Harris, C Juchem, R Kreis… - NMR in …, 2021 - Wiley Online Library
Once an MRS dataset has been acquired, several important steps must be taken to obtain
the desired metabolite concentration measures. First, the data must be preprocessed to …

Advanced processing and simulation of MRS data using the FID appliance (FID‐A)—an open source, MATLAB‐based toolkit

R Simpson, GA Devenyi, P Jezzard… - Magnetic resonance …, 2017 - Wiley Online Library
Purpose To introduce a new toolkit for simulation and processing of magnetic resonance
spectroscopy (MRS) data, and to demonstrate some of its novel features. Methods The FID …

Gannet: A batch‐processing tool for the quantitative analysis of gamma‐aminobutyric acid–edited MR spectroscopy spectra

RAE Edden, NAJ Puts, AD Harris… - Journal of magnetic …, 2014 - Wiley Online Library
Purpose The purpose of this study is to describe the Gannet toolkit for the quantitative batch
analysis of gamma‐aminobutyric acid (GABA)‐edited MRS data. Materials and Methods …

Frequency and phase drift correction of magnetic resonance spectroscopy data by spectral registration in the time domain

J Near, R Edden, CJ Evans, R Paquin… - Magnetic resonance …, 2015 - Wiley Online Library
Purpose Frequency and phase drifts are a common problem in the acquisition of in vivo
magnetic resonance spectroscopy (MRS) data. If not accounted for, frequency and phase …

Big GABA: Edited MR spectroscopy at 24 research sites

M Mikkelsen, PB Barker, PK Bhattacharyya, MK Brix… - Neuroimage, 2017 - Elsevier
Magnetic resonance spectroscopy (MRS) is the only biomedical imaging method that can
noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid …

Hippocampal GABA enables inhibitory control over unwanted thoughts

TW Schmitz, MM Correia, CS Ferreira… - Nature …, 2017 - nature.com
Intrusive memories, images, and hallucinations are hallmark symptoms of psychiatric
disorders. Although often attributed to deficient inhibitory control by the prefrontal cortex …

Glutathione in the human brain: Review of its roles and measurement by magnetic resonance spectroscopy

CD Rae, SR Williams - Analytical biochemistry, 2017 - Elsevier
We review the transport, synthesis and catabolism of glutathione in the brain as well as its
compartmentation and biochemistry in different brain cells. The major reactions involving …

GABA shapes the dynamics of bistable perception

AM van Loon, T Knapen, HS Scholte, ES John-Saaltink… - Current Biology, 2013 - cell.com
Sometimes, perception fluctuates spontaneously between two distinct interpretations of a
constant sensory input. These bistable perceptual phenomena provide a unique window …