Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: pathogenic implications in atopic dermatitis
M Furue - International journal of molecular sciences, 2020 - mdpi.com
Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …
IL-24: A new player in the pathogenesis of pro-inflammatory and allergic skin diseases
Y Mitamura, S Nunomura, M Furue… - Allergology …, 2020 - jstage.jst.go.jp
abstract Interleukin (IL)-24 is a member of the IL-20 family of cytokines and is produced by
various types of cells, such as CD4þ T cells, NK cells, mast cells, keratinocytes, bronchial …
various types of cells, such as CD4þ T cells, NK cells, mast cells, keratinocytes, bronchial …
Periostin is induced by IL-4/IL-13 in dermal fibroblasts and promotes RhoA/ROCK pathway-mediated TGF-β1 secretion in abnormal scar formation
D Maeda, T Kubo, K Kiya, K Kawai… - Journal of plastic …, 2019 - Taylor & Francis
Excess scar formation can occur after skin injur ふ y and lead to abnormal scar formation,
such as keloids and hypertrophic scars, which are characterised by substantial deposition of …
such as keloids and hypertrophic scars, which are characterised by substantial deposition of …
Mirabegron, dependent on β3-adrenergic receptor, alleviates mercuric chloride-induced kidney injury by reversing the impact on the inflammatory network, M1/M2 …
MM Kamal, HS El-Abhar, DM Abdallah… - International …, 2024 - Elsevier
The β3-adrenergic receptor (β3-AR) agonism mirabegron is used to treat overactive urinary
bladder syndrome; however, its role against acute kidney injury (AKI) is not unveiled, hence …
bladder syndrome; however, its role against acute kidney injury (AKI) is not unveiled, hence …
Spinal interleukin-24 contributes to neuropathic pain after peripheral nerve injury through interleukin-20 receptor2 in mice
Y Cai, C He, Y Dai, D Zhang, G Lv, H Lu, G Chen - Experimental Neurology, 2024 - Elsevier
Neuroinflammation is critically involved in nerve injury-induced neuropathic pain,
characterized by local and systemic increased levels of proinflammatory cytokines …
characterized by local and systemic increased levels of proinflammatory cytokines …
Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is a widespread genetic disease
that leads to renal failure in the majority of patients. The very first pharmacological treatment …
that leads to renal failure in the majority of patients. The very first pharmacological treatment …
Advances in the progression and prognosis biomarkers of chronic kidney disease
Z Yan, G Wang, X Shi - Frontiers in Pharmacology, 2021 - frontiersin.org
Chronic kidney disease (CKD) is one of the increasingly serious public health concerns
worldwide; the global burden of CKD is increasingly due to high morbidity and mortality. At …
worldwide; the global burden of CKD is increasingly due to high morbidity and mortality. At …
Novel targets for therapy of renal fibrosis
N Prakoura, J Hadchouel… - … of Histochemistry & …, 2019 - journals.sagepub.com
Renal fibrosis is an important component of chronic kidney disease, an incurable pathology
with increasing prevalence worldwide. With a lack of available therapeutic options, end …
with increasing prevalence worldwide. With a lack of available therapeutic options, end …
Renal expression of JAK2 is high in polycystic kidney disease and its inhibition reduces cystogenesis
F Patera, A Cudzich-Madry, Z Huang, M Fragiadaki - Scientific reports, 2019 - nature.com
Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal genetic
disorder, however it still lacks a cure. The discovery of new therapies heavily depends on …
disorder, however it still lacks a cure. The discovery of new therapies heavily depends on …
STAT signaling in polycystic kidney disease
The most common form of polycystic kidney disease (PKD) in humans is caused by
mutations in the PKD1 gene coding for polycystin1 (PC1). Among the many identified or …
mutations in the PKD1 gene coding for polycystin1 (PC1). Among the many identified or …