The growing accessibility and falling costs of genetic sequencing techniques has expanded
the utilization of genetic testing in clinical practice. For living kidney donation, genetic …

Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …

Ever since the discovery of the major histocompatibility complex, scientific and clinical
understanding in the field of transplantation has been advanced through genetic and …

This meeting report from the XV Banff conference describes the creation of a multiorgan
transplant gene panel by the Banff Molecular Diagnostics Working Group (MDWG). This …

Kidney failure, the decrease of kidney function below a threshold necessary to support life, is
a major cause of morbidity and mortality. We performed a genome-wide association study …

Background To seek insights into the pathogenesis of chronic active antibody–mediated
rejection (CAMR), we performed mRNA analysis and correlated transcripts with pathologic …

Background In kidney transplant recipients, surveillance biopsies can reveal, despite stable
graft function, histologic features of acute rejection and borderline changes that are …

Donor-recipient (DR) mismatches outside of human leukocyte antigens (HLAs) contribute to
kidney allograft loss, but the mechanisms remain unclear, specifically for intronic …

Large-scale whole-genome sequence data sets offer novel opportunities to identify genetic
variation underlying human traits. Here we apply genotype imputation based on whole …

Genome-wide association studies (GWAS) have identified hundreds of loci associated with
kidney-related traits such as glomerular filtration rate, albuminuria, hypertension, electrolyte …