Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
Effects of N-glycan modifications on spike expression, virus infectivity, and neutralization sensitivity in ancestral compared to Omicron SARS-CoV-2 variants
S Lusvarghi, CB Stauft, R Vassell, B Williams… - PLoS …, 2023 - journals.plos.org
The SARS-CoV-2 spike glycoprotein has 22 potential N-linked glycosylation sites per
monomer that are highly conserved among diverse variants, but how individual glycans …
monomer that are highly conserved among diverse variants, but how individual glycans …
SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity
The glycosylation of viral envelope proteins can play important roles in virus biology and
immune evasion. The spike (S) glycoprotein of severe acute respiratory syndrome …
immune evasion. The spike (S) glycoprotein of severe acute respiratory syndrome …
[HTML][HTML] Evolving spike-protein N-glycosylation in SARS-CoV-2 variants
Abstract Since> 3 years, SARS-CoV-2 has plunged humans into a colossal pandemic.
Henceforth, multiple waves of infection have swept through the human population, led by …
Henceforth, multiple waves of infection have swept through the human population, led by …
Towards a molecular picture of the archaeal cell surface
Archaea produce various protein filaments with specialised functions. While some archaea
produce only one type of filament, the archaeal model species Sulfolobus acidocaldarius …
produce only one type of filament, the archaeal model species Sulfolobus acidocaldarius …
Role of N343 glycosylation on the SARS-CoV-2 S RBD structure and co-receptor binding across variants of concern
Glycosylation of the SARS-CoV-2 spike (S) protein represents a key target for viral evolution
because it affects both viral evasion and fitness. Successful variations in the glycan shield …
because it affects both viral evasion and fitness. Successful variations in the glycan shield …
Structural and Functional Insights into the Evolution of SARS-CoV-2 KP. 3.1. 1 Spike Protein
The JN. 1-sublineage KP. 3.1. 1 recently emerged as the globally prevalent SARS-CoV-2
variant, demonstrating increased infectivity and antibody escape. We investigated how …
variant, demonstrating increased infectivity and antibody escape. We investigated how …
Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses
Understanding the zoonotic risks posed by bat coronaviruses (CoVs) is critical for pandemic
preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) …
preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) …
Enhanced surface accessibility of SARS-CoV-2 Omicron spike protein due to an altered glycosylation profile
SARS-CoV-2 spike (S) proteins undergo extensive glycosylation, aiding in proper folding,
enhancing stability, and evading host immune surveillance. In this study, we used mass …
enhancing stability, and evading host immune surveillance. In this study, we used mass …
The HCoV-HKU1 N-Terminal Domain Binds a Wide Range of 9-O-Acetylated Sialic Acids Presented on Different Glycan Cores
I Tomris, ALM Kimpel, R Liang… - ACS Infectious …, 2024 - ACS Publications
Coronaviruses (CoVs) recognize a wide array of protein and glycan receptors by using the
S1 subunit of the spike (S) glycoprotein. The S1 subunit contains two functional domains: the …
S1 subunit of the spike (S) glycoprotein. The S1 subunit contains two functional domains: the …