The role of genetic and epigenetic factors in tumor initiation and progression is well
documented. Histone deacetylases (HDACs), histone methyl transferases (HMTs), and DNA …

A neuroblastoma (NB) is a solid paediatric tumour arising from undifferentiated neuronal
cells. Despite the recent advances in disease management and treatment, it remains one of …

Retinoids (vitamin A) have been reported extensively for anti-cancer properties due to their
high receptor-binding affinities and gene regulation abilities. However, the anti-cancer …

Neuroblastoma (NB) is the most common extracranial solid tumor often diagnosed in
childhood. Despite intense efforts to develop a successful treatment, current available …

In this article, we describe contrasting developmental aspects of paediatric and adult brain
tumours. We hypothesize that the formation of cancer progenitor cells, for both paediatric …

Cancer is a systemic heterogeneous disease that can undergo several rounds of latency
and activation. Tumor progression evolves by increasing diversity, adaptation to signals from …

Brain cancers are the leading cause of cancer-related deaths in children. Biological
changes in these tumors likely include epigenetic deregulation during embryonal …

Abstract Development of vertebrate nervous system is a complex process which involves
differential gene expression and disruptions in this process or in the mature brain, may lead …

Epigenetic mechanisms, including post-translational modifications of DNA and histones that
influence chromatin structure, regulate gene expression during normal development and are …

Background Upstream open reading frames (uORFs) initiate translation within mRNA 5′
leaders, and have the potential to alter main coding sequence (CDS) translation on …