Cyclin dependent kinase 9 (CDK9) plays an essential role in regulating transcriptional
elongation. Aberrations in CDK9 activity have been observed in various cancers, which …

CDK9 is a cyclin-dependent kinase that plays pivotal roles in multiple cellular functions
including gene transcription, cell cycle regulation, DNA damage repair, and cellular …

Abstract Cyclin-dependent kinase 9 (CDK9) plays a vital role in controlling cell transcription
and has been an attractive target for cancer treatment. Herein, ten predictive models derived …

Aim: A fragment-based design and synthesis of three novel series of aminopyridone-linked
benzimidazoles as potential anticancer candidates with significant CDK9 inhibition was …

An efficient, facile, and eco-friendly synthesis of pyrimidine derivatives has been developed.
It involves a [3+ 2+ 1] three-component annulation of amidines, ketones, and one carbon …

Specific inhibition on CDK9 has been proven to be a promising targeted cancer therapy. In
this work, fourteen novel 2, 4-disubstituted pyrimidine derivatives were designed and …

CDK2/9 are members of the CDKs family, which play key roles in the occurrence and
development of many cancers by regulating cell cycle and transcriptional prolongation …

Deep Eutectic Solvent (DES)-like mixtures, based on glycerol and different halide organic
and inorganic salts, are successfully exploited as new media in copper-free …

The global burden of cancer necessitates rapid and ongoing development of effective
cancer therapies. One promising approach in this context is the repurposing of existing non …

Cyclin-dependent kinases (CDKs) constitute a vital family of protein-serine kinases, pivotal
in regulating various cellular processes such as the cell cycle, metabolism, proteolysis, and …