The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

Diabetes mellitus-related cardiomyopathy (DMCMP) was originally described as a dilated
phenotype with eccentric left ventricular (LV) remodelling and systolic LV dysfunction …

Objective Ferroptosis is indicated in cardiovascular diseases. Given the prominent role of
mitophagy in the governance of ferroptosis and our recent finding for FUN14 domain …

The network for cardiac fuel metabolism contains intricate sets of interacting pathways that
result in both ATP-producing and non–ATP-producing end points for each class of energy …

Heart disease is a leading cause of death worldwide. In many forms of heart disease,
including heart failure, ischaemic heart disease and diabetic cardiomyopathies, changes in …

Cardiac metabolism is highly adaptive to changes in fuel availability and the energy demand
of the heart. This metabolic flexibility is key for the heart to maintain its output during the …

The prevalence of cardiomyopathy is higher in diabetic patients than those without diabetes.
Diabetic cardiomyopathy (DCM) is defined as a clinical condition of abnormal myocardial …

Background—Cardiac hypertrophy is accompanied by significant alterations in energy
metabolism. Whether these changes in energy metabolism precede and contribute to the …

Triacylglycerol (TAG) is the primary unit of energy storage in eukaryotic cells. TAG comprises
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …

A fine balance between uptake, storage, and the use of high energy fuels, like lipids, is
crucial in the homeostasis of different metabolic tissues. Nowhere is this balance more …