The ins and outs of antigen uptake in B cells

AN McShane, D Malinova - Frontiers in immunology, 2022 - frontiersin.org
A review of our current knowledge of B cell antigen uptake mechanisms, the relevance of
these processes to pathology, and outstanding questions in the field. Specific antigens …

Potential pathogenic impact of cow's milk consumption and bovine milk-derived exosomal MicroRNAs in diffuse large B-Cell lymphoma

BC Melnik, R Stadler, R Weiskirchen… - International Journal of …, 2023 - mdpi.com
Epidemiological evidence supports an association between cow's milk consumption and the
risk of diffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin lymphoma …

Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells

FY Maeda, JJH van Haaren, DB Langley, D Christ… - Elife, 2021 - elifesciences.org
Abstract B-cell receptor (BCR)-mediated antigen internalization and presentation are
essential for humoral memory immune responses. Antigen encountered by B-cells is often …

Potent neutralization by monoclonal human IgM against SARS‐CoV‐2 is impaired by class switch

I Callegari, M Schneider, G Berloffa, T Mühlethaler… - EMBO …, 2022 - embopress.org
To investigate the class‐dependent properties of anti‐viral IgM antibodies, we use
membrane antigen capture activated cell sorting to isolate spike‐protein‐specific B cells …

Biology of endophilin and it's role in disease

LQ Yang, AF Huang, WD Xu - Frontiers in Immunology, 2023 - frontiersin.org
Endophilin is an evolutionarily conserved family of protein that involves in a range of
intracellular membrane dynamics. This family consists of five isoforms, which are distributed …

Endophilin A2 Deficiency Impairs Antibody Production in Humans

C Mehawej, E Chouery, R Farah, A Khalil… - Journal of Clinical …, 2025 - Springer
Endophilin A2, the sole endophilin A family member expressed in hematopoietic cells,
regulates various aspects of membrane dynamics, including autophagy and endocytosis …

B cell receptor (BCR) endocytosis

AD Roberts, JW Taraska - Progress in Molecular Biology and Translational …, 2023 - Elsevier
The B cell receptor (BCR) interacts with foreign antigens to mediate B cell activation and
secretion of antibodies. B cell activation begins with initiation of signaling pathways, such as …

Proteomic profile in plasma as a biomarker of pregnancy in cows

W Mojsym, J Wawrzykowski… - … in Domestic Animals, 2024 - Wiley Online Library
Pregnancy has its own protein dynamics, reflecting the hormonal profile. Quantitative and
qualitative changes in plasma protein profile may provide useful information about this …

Antigen mobility regulates the dynamics and precision of antigen capture in the B cell immune synapse

HCW McArthur, M Iliopoulou, AT Bajur, KM Spillane - bioRxiv, 2024 - biorxiv.org
B cells discriminate antigens in immune synapses by capturing them from antigen-
presenting cells. This discrimination relies on the application of mechanical force to B cell …

Survival pathways harnessed by Follicular Lymphoma and Transformed Follicular Lymphoma

L Wasim - 2023 - discovery.ucl.ac.uk
The genetic processes that allow for B-cell humoral immunity can also result in genetic
aberrations leading to B-cell lymphoma. Follicular lymphoma (FL) is a common non …