Small molecule selenium-containing compounds: Recent development and therapeutic applications

H Chuai, SQ Zhang, H Bai, J Li, Y Wang, J Sun… - European Journal of …, 2021 - Elsevier
Selenium (Se) is an essential micronutrient of organism and has important function. It
participates in the functions of selenoprotein in several manners. In recent years, Se has …

[HTML][HTML] Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment

V Gandin, P Khalkar, J Braude… - Free Radical Biology and …, 2018 - Elsevier
Selenium (Se)-containing compounds have attracted a growing interest as anticancer
agents over recent decades, with mounting reports demonstrating their high efficacy and …

Selenium compounds as therapeutic agents in cancer

AP Fernandes, V Gandin - Biochimica et Biophysica Acta (BBA)-General …, 2015 - Elsevier
Background With cancer cells encompassing consistently higher production of reactive
oxygen species (ROS) and with an induced antioxidant defense to counteract the increased …

The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents

M Mitsiogianni, G Koutsidis, N Mavroudis, DT Trafalis… - Antioxidants, 2019 - mdpi.com
Many studies have shown evidence in support of the beneficial effects of phytochemicals in
preventing chronic diseases, including cancer. Among such phytochemicals, sulphur …

Mechanisms of selenium enrichment and measurement in brassicaceous vegetables, and their application to human health

M Wiesner-Reinhold, M Schreiner… - Frontiers in Plant …, 2017 - frontiersin.org
Selenium (Se) is an essential micronutrient for human health. Se deficiency affects hundreds
of millions of people worldwide, particularly in developing countries, and there is increasing …

Synthesis and biological evaluation of organoselenium (NSAIDs-SeCN and SeCF3) derivatives as potential anticancer agents

X He, M Zhong, S Li, X Li, Y Li, Z Li, Y Gao… - European Journal of …, 2020 - Elsevier
A series of organoselenium compounds based on the hybridization of nonsteroidal
antiinflammatory drugs (NSAIDs) scaffolds and Se functionalities (-SeCN and-SeCF 3) were …

Selenocompounds in cancer therapy: an overview

D Bartolini, L Sancineto, AF de Bem, KD Tew… - Advances in Cancer …, 2017 - Elsevier
In vitro and in vivo experimental models clearly demonstrate the efficacy of Se compounds
as anticancer agents, contingent upon chemical structures and concentrations of test …

Therapeutic nanocarriers with hydrogen peroxide-triggered drug release for cancer treatment

J Liu, Y Pang, Z Zhu, D Wang, C Li, W Huang… - …, 2013 - ACS Publications
Chemotherapy is an important modality in cancer treatment. The major challenge of recent
works in this research field is to develop new types of smart nanocarriers that can respond …

The PTEN–AKT3 signaling cascade as a therapeutic target in melanoma

SRV Madhunapantula… - Pigment cell & melanoma …, 2009 - Wiley Online Library
Melanocytes undergo extensive genetic changes during transformation into aggressive
melanomas. These changes deregulate genes whose aberrant activity promotes the …

Organoselenium compounds in medicinal chemistry

C Gallo‐Rodriguez, JB Rodriguez - ChemMedChem, 2024 - Wiley Online Library
The chemical and biological interest in this element and the molecules bearing selenium
has been exponentially growing over the years. Selenium, formerly designated as a toxin …